?”..The results showed that both the runners and bicyclists had 80% more anandamide in their blood after exercising, with the greatest increase among the runners. They also reported physical feelings similar to marijuana use, such as relaxation, regulated mood, and increased appetite. Plus, they found that tempo running produced the most anandamide of all exercise …” Continue reading
Reversing his previous position that “pot is no big deal”.
Kennedy says, “I admit it—I was wrong to initially think that there was there were something harmless about medical marijuana because now what I’ve seen is that there is a commercial industry behind this “medical marijuana” soon to be moving down the track as it has in Washington, and Colorado, fully legalized…”
“My fight has been about mental health and treating addiction…”
He starts speaking to facts, and his facts are wrong.
But he did get the part about Washington and Pharma taking over. First they banned it. Now they control it. Pharma serves it.
“In 1936 the Federal Bureau of Narcotics (FBN) noticed an increase of reports of people smoking marijuana, which further increased in 1937. The Bureau drafted a legislative plan for Congress seeking a new law, and the head of the FBN, Harry J. Anslinger, ran a campaign against marijuana. Newspaper mogul William Randolph Hearst‘s empire of newspapers used the “yellow journalism” pioneered by Hearst to demonize the cannabis plant and spread a public perception that there were connections between cannabis and violent crime.“
However, in 1949 the government was aware that marijuana was effective as medical treatment for epilepsy. The study was squelched.
As previous studies demonstrated that individuals with high subjective happiness level rated their current affective states more positively when they experience positive events, these two aspects of happiness are interrelated.
According to a recent neuroimaging study, the cytosine to thymine single-nucleotide polymorphism of the human cannabinoid receptor 1 gene is associated with sensitivity to positive emotional stimuli.
Thus, we hypothesized that our genetic traits, such as the human cannabinoid receptor 1 genotypes, are closely related to the two aspects of happiness.
In Experiment 1, 198 healthy volunteers were used to compare the subjective happiness level between cytosine allele carriers and thymine-thymine carriers of the human cannabinoid receptor 1 gene.
In Experiment 2, we used positron emission tomography with 20 healthy participants to compare the brain responses to positive emotional stimuli of cytosine allele carriers to that of thymine-thymine carriers.
Compared to thymine-thymine carriers, cytosine allele carriers have a higher subjective happiness level. Regression analysis indicated that the cytosine allele is significantly associated with subjective happiness level.
The positive mood after watching a positive film was significantly higher for the cytosine allele carriers compared to the thymine-thymine carriers.
Positive emotion-related brain region such as the medial prefrontal cortex was significantly activated when the cytosine allele carriers watched the positive film compared to the thymine-thymine carriers.
Thus, the human cannabinoid receptor 1 genotypes are closely related to two aspects of happiness. Compared to thymine-thymine carriers, the cytosine allele carriers of the human cannabinoid receptor 1 gene, who are sensitive to positive emotional stimuli, exhibited greater magnitude positive emotions when they experienced positive events and had a higher subjective happiness level.
Cannabis calms the excess electrical activity in young developing minds.
In March, my husband Darryl and I took to the road to capture the stories of several North Carolina families hoping to treat their children with cannabis.
Most of the children we met suffered from debilitating epilepsy, then there are those with epilepsy and leukemia, and others with epilepsy and either ADD or autism or both. Continue reading
In March, Darryl and I made a video interviewing North Carolina families with children who suffer from life threatening seizures who all want to bring CBD oil to North Carolina. That video made it to North Carolina Representative Pat McElraft who is working on “Hope for Haley”—for Haley who lives in her district.
State lawmakers last year defeated a bill that would have legalized “medical marijuana” in North Carolina. Continue reading
In the words of Dr. Sanjay Gupta, practicing neurosurgeon and CNN’s chief medical correspondent, “this scientific journey is about a growing number of patients who want the cannabis plant as a genuine medicine, not to get high.”
“It is about emerging science that not only shows and proves what marijuana can do for the body but provides better insights into the mechanisms of marijuana in the brain, helping us better understand a plant whose benefits have been documented for thousands of years. This journey is also about a Draconian system where politics override science and patients are caught in the middle.”
“She was in good enough shape to be there and be present. In the House when all the representatives stood up and gave her a round of applause, she perked up like she knew it was for her.”
Froerer said some representatives “really broke down” when they saw Charlee brought to the floor in a wheelchair.
Cannabis oil wouldn’t have cured Charlee, but it might have calmed her seizures and prolonged her life.
Darryl and I drove around North Carolina and interviewed these families about their experiences as parents of a child with epilepsy. These parents are fighting to be able to use cannabis as a treatment—several North Carolina families have moved to Colorado (for access to legal marijuana) with the children having great success.
#kidsforcannabis #kidswithcancer #kidswithepilepsy #kidswithautism #hope4kids #cannabis #THC #CBD
Update! See “Hope for Haley“.
Reprint from Salt Lake City Telegram, May 20, 1949
Drug principles isolated from leaves of marijuana, an innocent-looking plant that grows wild in different parts of the world, are playing an important role in research on a cure for epilepsy.
This is the same marijuana which so many people fear as a habit-forming drug and which is noted for the opium-like dreams it produces in those who partake of it.
“The public is starting to understand what this is. The political fear is shifting from what will happen if we pass it, to might what happen if we don’t.”
While families across the United States are broken as a mother and child move to Colorado, from their home states where medical marijuana is not legal, for non-psychoactive high CBD oil anecdotally proven to stop seizures, an Arizona family is being harassed by local state officials and Maricopa County Attorney William Montgomery…
The Welton family received a medical marijuana card from the state for their son Zander in September and began treatment with cannabidiol (high CBD oil) with great results. Continue reading
“If you would have asked me a year ago if I would have had my daughter on marijuana I would have thought you were crazy. I mean, really?” said Maria Botker. “But when you have put your daughter through something as scary as brain surgery like we did with Greta about three years ago, this seems like nothing, really nothing.”
Six-year-old Braxton Ried has Dravet Syndrome, a rare and catastrophic form of epilepsy that begins in infancy. His parents, Ben and Misty Ried, say he has a couple a month—but every seizure he has is so violent, it becomes potentially deadly. He is often hospitalized and on life support after suffering from one.
Molly Grantham’s WBTV report on Medical Marijuana for North Carolina kids
Both Maria and Liz are two moms of roughly 150-200 nationwide who have their children on “Charlotte’s Web”, a natural cannabis treatment for, among other things, pediatric epilepsy. Early success stories of families who have tried everything else and seen nothing work on their children’s epilepsy, say it could be a miracle drug.
But, it’s illegal in the Carolinas because it’s made from marijuana.
Both Maria and Liz moved with their children. Both had to leave their husbands for their jobs.
“It comes from cannabis,” says Liz. “But children don’t smoke it. It’s a liquid medicine. We give it to our children like other parents give Tylenol. And most importantly, it only has trace amounts of THC. You can’t get ‘high’ from taking Charlotte’s Web. Having tried it now and having had to move across country to get it, I honestly feel this is ridiculous we can’t have it everywhere.”
- “Realm of Caring” waiting list for Charlotte’s Web
- Hope 4 Kids NC Facebook page for North Carolina parents trying to get information on medical marijuana and high-CBD marijuana.
MontanaPBS’s new documentary, Clearing the Smoke, reveals how cannabis acts on the brain and in the body to treat nausea, pain, epilepsy and potentially even cancer. Extensive interviews with patients, doctors, researchers and skeptics detail the promises and the limitations of medicinal cannabis.
The incredible stories of two pediatric cannabis patients which will revolutionize the way that the world views the cannabis plant.
Hear from two mother’s who were both told by doctors “there’s nothing else we can do”. Continue reading
84% of the parents surveyed reported a reduction in their child’s seizure frequency while taking cannabidiol-enriched cannabis.
Severe childhood epilepsies are characterized by frequent seizures, neurodevelopmental delays, and impaired quality of life. In these treatment-resistant epilepsies, families often seek alternative treatments.
In the December 2013 issue of the journal Epilepsy and Behavior, Drs. Porter and Jacobsen from Stanford University investigate the use of cannabidiol-enriched cannabis in children with treatment-resistant epilepsy.
The survey was presented to parents belonging to a Facebook group dedicated to sharing information about the use of cannabidiol-enriched cannabis to treat their child’s seizures.
Nineteen responses met the following inclusion criteria for the study: a diagnosis of epilepsy and current use of cannabidiol-enriched cannabis.
The average number of antiepileptic drugs (AEDs) tried before using cannabidiol-enriched cannabis was 12.
- Sixteen (84%) of the 19 parents reported a reduction in their child’s seizure frequency while taking cannabidiol-enriched cannabis.
- Of these, two (11%) reported complete seizure freedom
- eight (42%) reported a greater than 80% reduction in seizure frequency
- six (32%) reported a 25-60% seizure reduction.
- Other beneficial effects included increased alertness, better mood, and improved sleep.
- Side effects included drowsiness and fatigue.
The survey shows that parents are using cannabidiol-enriched cannabis as a treatment for their children with treatment-resistant epilepsy.
Because of the increasing number of states that allow access to medical cannabis, its use will likely be a growing concern for the epilepsy community. Safety and tolerability data for cannabidiol-enriched cannabis use among children are not available.
Objective measurements of a standardized preparation of pure cannabidiol are needed to determine whether it is safe, well tolerated, and efficacious at controlling seizures in this pediatric population with difficult-to-treat seizures.
Keywords: Cannabidiol, Dravet syndrome, Epilepsy, Intractable, Medically refractory seizures, Pediatric, Side effects, Treatment-resistant
Brenda E. Porter, Catherine Jacobson, Epilepsy & Behavior, Volume 29, Issue 3, December 2013, Pages 574-577, ISSN 1525-5050, http://dx.doi.org/10.1016/j.yebeh.2013.08.037. (http://www.sciencedirect.com/science/article/pii/S1525505013004629)
Photo by CNN.
Featuring Michael Pollan and based on his best-selling book, The Botany of Desire: A Plant’s-Eye View of the World, this special takes viewers on an eye-opening exploration of the human relationship with the plant world, seen from the plants’ point of view of four familiar species—the apple, the tulip, cannabis and the potato.
Brazilian Journal of Medical and Biological Research On-line version ISSN 1414-431X
Braz J Med Biol Res vol.39 no.4 Ribeirão Preto Apr. 2006
http://dx.doi.org/10.1590/S0100-879X2006000400001 Continue reading
U.S. Rep. Walter Jones has taken up the case of a number of desperate North Carolina parents who are hoping state lawmakers will legalize medicinal marijuana for children with uncontrollable seizures. Continue reading
Liz Gorman, and her daughter, Maddie, moved from North Carolina to Colorado where they can access a strain of marijuana meant to help with severe epilepsy:
“We’d love to see it legalized in North Carolina so we can come home.”
“Overly polite” suspect wins appeal; search of car was illegal, court rules
CHARLOTTE, N.C. — As people in Colorado line up to buy recreational marijuana for the first time in the nation, families in the Carolinas are pushing lawmakers to bring a form of medical marijuana here.
Michael Saffioti, 22, died in his cell at Snohomish County Jail last year after eating oatmeal that triggered his debilitating dairy allergy. His family claims in a lawsuit that guards ignored his calls for help and recklessly disregarded the seriousness of his condition.
Michael begged for help from his cell at Snohomish County Jail after eating some oatmeal that triggered his debilitating dairy allergy on July 2, 2012, but was ignored by guards until it was too late, a video obtained by local KIRO-7 TV shows.
The day before he died, Saffioti had turned himself into Lynnwood police for missing a court date on a misdemeanor pot bust.
Four months after Michael’s death recreational use was legalized in Washington state. Continue reading
Governments and drug companies are loath to fund the research needed to bring the drug into general use—Israel offers ideal conditions for such research.
“We in Israel have an opportunity, and vast responsibility, when it comes to international research about medical cannabis. Israel has a government-sponsored medical cannabis program and a convenient regulatory climate for research. We also have the health maintenance organizations, which possess rare databases of precious information about the effects of cannabis on thousands of patients who have undergone that treatment.”—Mimi Peleg Continue reading
Dr. Sanjay Gupta says we have been “systematically misled” on marijuana… Take the case of Charlotte Figi, who he met in Colorado. She started having seizures soon after birth. By age 3, she was having 300 a week, despite being on seven different medications. Medical marijuana has calmed her brain, limiting her seizures to 2 or 3 per month.
This post is prompted tonight by my personal experience with…
“not bringing reproach upon Jehovah’s organization”.
Most Jehovah’s Witnesses
have no idea there are 24,000+ pedophiles who have hidden among the silent lambs
in their congregations…
San Diego ABC 10 News reported obtaining video of admitted child molester Jehovah’s Witness Gonzalo Campos.
“I did abuse him,” said Campos in the video. “I touched his private parts.
Testimony of Gonzalo Campos
Accused JW pedophile confession on camera released by San Diego ABC 10 News.
Team 10 asked if Zalkin believed it’s widely known that there are sexual abuse problems inside Jehovah’s Witnesses.
“No, no and it needs to be brought to the public’s attention,” Zalkin said. “They have been operating in secrecy and at will for decades.”
I wonder what God is going to do with marijuana in eternity.
Out of all humanity alive today, I wonder what percentage DOESN’T take a pharmaceutical prescription? Remember, someone dies in the United States every 19 minutes from a prescription drug overdose, mostly accidental.
God created marijuana, and Christ warned about *pharmakeia* in the last days (Revelation 9:21, 18:23, 21:8, 22:15; Galatians 5:19-22) as “sorcery” by which “all the nations were deceived”.
Sounds like the pharmaceutical industry, doesn’t it?
Certainly “all nations” aren’t going to be deceived by God’s own creation: “nor height nor depth **nor any other creation** will be able to separate us from God’s love that is in Christ Jesus our Lord.”
“For **the creation** was subjected to futility, not by its own will but through him that subjected it, on the basis of hope that the creation itself also will be set free from enslavement to corruption and have the glorious freedom of the children of God. For we know that **all creation** keeps on groaning together and being in pain together until now.”
God created coca leaves—coco leaves are soaked in gasoline and sulfuric acid to produce the substance cocaine.
My Peruvian acupuncturist had me chew coco leaves to adjust to altitude for the hike to Machu Picchu.
Even Sanjay Gupta, MD finally does research instead of simply following the crowd.
Published: Saturday, September 21, 2013 at 10:00 p.m.
North Carolina parents of children who suffer severe seizures are lining up for access to and pushing for legalization of medical marijuana where it’s not already allowed.
They want people to know they’re not radicals. And they’re not going rogue. They are searching for options.
They freely admit they are desperate parents staring down nightmares with their children, having watched them develop early skills only to lose them at the hands of numerous seizures, only to have tried cocktails of medications with debilitating side effects and watch them not work.
They want the option legal in this state to try medical marijuana. They want it so they aren’t forced to uproot and move to another state where it’s legal, where there’s been early success in treating seizure disorders. Continue reading
Orrin Devinsky MD, Director of the Comprehensive Epilepsy Center at New York University, was recently awarded FDA approval to conduct a clinical trial that will study the safety and tolerability of cannabidiol (CBD) in children with epilepsy.
“At this point, I think we really lack much data,” said Devinsky, who points to promising results in animals, but says the real push came from the anecdotal evidence provided by parents in Colorado.
“I’ve spoken with these parents, and I think they’re solid, good, loving parents, who’ve had very good experiences. Whether this will be borne out by scientific studies is uncertain,” he said.
Dr. Alan Shackelford oversaw the treatment of nine-month-old Kaitlyn Pogson’s Dravet syndrome, a type of epilepsy that causes her to have 300 seizures per week, administering high-CBD medical marijuana to the infant.
“The response was instantaneous,” Shackelford told the Star by telephone. “After the first dose, the seizures stopped … and she didn’t suffer a seizure for seven days.”
Charlotte now suffers one seizure every other week, Shackelford says, “a remarkable and heretofore unprecedented change.”
Americans for Safe Access continues the discussion begun by CNN and Dr. Sanjay Gupta documentary “WEED”. The Google Hangout featured many of the same guests in the documentary as well as additional experts in the medical cannabis field.
For more information please visit www.peace4patients.org.
Despite its status as one of the world’s leading nations for medical research and innovation, the United States has a remarkably restrictive system in place to regulate medicinal cannabis research.
Even when the US Food and Drug Administration (FDA) approves medicinal cannabis studies, the researcher or institution must then obtain approval from the Public Health Service (PHS), as well as procure cannabis material from the National Institute on Drug Abuse (NIDA), which has a monopoly on the supply of cannabis that can be used for research throughout the entire country.1
Cannabis (Cannabis spp. Cannabaceae) is the only scheduled substance for which PHS approval is required, and those wishing to study the plant often have been rejected by the agency — effectively quelling this important area of science.
An increasing number of US states have taken matters into their own hands by legalizing medicinal cannabis for residents with certain health conditions.
But the federal government continues to raid and shut down state-based medicinal cannabis operations, even sending some of these business owners to prison.
Although the US situation is largely based on the discrepancy between state and federal law, Americans and citizens of other countries that ban medicinal cannabis could learn just how successfully, compassionately — and non-controversially — such a program can be handled by looking at the unique national medicinal cannabis program in Israel.
Vaporize. I call it “neuraromatherapy”.
Cannabis, like tobacco, contains toxins that are known to be hazardous to the respiratory system. Among them are the highly carcinogenic polynuclear aromatic hydrocarbons, a prime suspect in cigarette-related cancers. These toxins are essentially a byproduct of combustion, separate from the pharmaceutically active components of marijuana, known as cannabinoids, which include THC.
Although there is no proof that marijuana smoking causes cancer, chronic pot smokers have been shown to suffer an elevated risk of bronchitis and respiratory infections. Respiratory disease due to smoking may therefore rightly be regarded as the primary physiological hazard of marijuana.
Cannabis vaporizers are designed to let users inhale active cannabinoids while avoiding harmful smoke toxins. They do so by heating cannabis to a temperature of 180 – 200° C (356° – 392° F), just below the point of combustion where smoke is produced. At this point, THC and other medically active cannabinoids are emitted with little or none of the carcinogenic tars and noxious gases found in smoke. Many medical marijuana patients who find smoked marijuana highly irritating report effective relief inhaling through vaporizers. Users who are concerned about the respiratory hazards of smoking are strongly advised to use vaporizers. Alternative devices, such as waterpipes, have been shown to be ineffective at reducing the tars in marijuana smoke (Report).
Herb or Herbal: “any plant with leaves, seeds, or flowers used for savoring, food, medicine, or perfume” or “a part of such a plant as used in cooking”. Botanists use the same term differently, for any non-woody flowering plant, regardless of its flavor, scent or other properties, and thus include only grass-like plants and herbs.
Herbal Vaporizer or Personal Herbal Vaporizer: A device designed to extract the essence or active compounds from a herb though the use of heat, rather than through burning or combustion.
LOW TEMPERATURE: up to 150C (302F)
- Angelica: 100C to 150C (212F to 302F).
- Black Horehound: 100C to 125C (212F to 257F)
- Blue Lotus: 100°C to 125°C (212°F to 257°F)
- Chamomile: 100C to 125C (212F to 257F)
- Clove: 125C to 150C (257F to 302F)
Dr. Kevin Beiko speaks at NC Legislative Education Forum on the topic, “Medical Cannabis in Carolina“.
If you watched this video and liked Addy, you can watch outtakes of her here: http://kiro.tv/WFNEMZ CNN may have just posted their best piece of investigative journalism in years. In the following video, three drivers of varying ages got incredibly high on marijuana and test-drove cars around a course. A driving-ed instructor accompanied them to avert any chance of an accident, and police watched from the sidelines to spot any visible ‘signs’ of inebriation in their movements.
The volunteers — a young daily smoker, adult weekend smoker and elder infrequent smoker — proceeded to test escalating levels of stupor against the new baseline ‘legal limits’ in Colorado and Washington state. They had to reach excesses of 5 times the legal limit before their ability to drive became impaired. In most cases, the danger they presented was driving too slowly or with frequent hesitations.
Real marijuana has never killed anyone.
A teenage girl from Texas suffered from multiple strokes after smoking synthetic marijuana – leaving her brain damaged, blind and paralyzed, the Independent reported. Continue reading
I am proud of my mother.
She challenged the authority when they told her that my uncle had six months to live.
In her heart, she knew better. In six weeks he was dead.
My mother didn’t fight the authority, there was no point. Either way, he’d be dead. Yet, my mother took her belief seriously. She rearranged her priorities, so that she could be with him not wanting to miss spending time with him while he still breathed.
My mother shared her belief with those of the family who would listen, and some believed what she, in faith, said. Because my mom is something of a natural nut, some chose to believe the word of the medical authority over what she so strongly believed.
My mother called us together, asking the family to gather, to spend time with him. The doctors had decreed his six months in July, my mom come and see him Memorial Day. I questioned my mother, asked her, is it Labor Day you mean? More than her words, I knew what she meant, what her belief would mean.
Those of who believed, who took the health nut my momma seriously, took heed. The family all gathered, and the other side of the family hosted, the ones who take my mom seriously. Amid music and singing, children playing and sunflowers, my aunt and uncle (of that side of the family) offered Uncle Randy relief in the form of a weed. Though it’s not an appropriate natural remedy in my mother’s belief, it was thanks to God’s creation that he was able to join in the merriment, raising a guitar to his knee. Before that day, I never he knew that he could really play.
Later I confessed to my mother that she must know that the pleasure thanks to the leaves of a weed. I urged her to urge his caregiver to implore his doctor to prescribe him the prescription, mans form of God’s gift by the hand of their own authority. My aunt, the caregiver, and my mother agreed, though the need was plain to see, relief shouldn’t be obtained in the form of what they’d call “weed“, they apparently don’t approve whether relief is by a pill form prescription or by what he’d breath, or eat. I’d never make it home fast enough to see about sending him cookies.
That was the last day I’d really see him, that day watching the last of his life—more so than any other day I’d ever seen—as he laughed and he played and he drank and even sang. That night, still relieved, apparently was the last and only he’d really sleep. Later I here he spent hours dead to the world, but even a caregiver, I imagine if I am bold, will note the difference between succumbing to death and breathing easy in sleep.
All this is to say, that I’m proud of my mother and that though they’d say that he’d have six months in this life to remain. My mother, though others would think her insane, ignored the authority and in her campaign we thus would win the last few days we’d never get back again. Those who’d doubt totally missed out, but my mother made sure we had all the time with him that we could spend.
I think of my mother happy that she’d challenge authority. What they said she simply couldn’t believe. They say that ‘faith is the assured expectation of things not yet beheld’, and it takes faith to believe.
Had my mother held to her faith, and urged us to believe, I wouldn’t have seen my uncle and get to say goodbye, in not so many words, before he’d leave.
My dear parents, my sisters and my brother, I’m glad we all listened to our mother, listened to her, trusted, had faith and believed—even though we weren’t raised to question authority.
I believe that we’ll all obtain life, given the lives we live, when we die. The difference is simply the reward you’ll obtain, by what words we heed while in this life we remain. I think of Nikki, who momma’s words didn’t heed, she heard but didn’t listen, and by doubt missed out because it was the doctor’s she chose to believe. She said she’d see him later, and though in this life she was wrong, I imagine that one day the band will get back together, and we all will be there to sing along.
I hope that you’ll respect me, as I take my leave from believing what I was taught is the authority. I asked them questions they couldn’t answer, so I’ll believe what I read. The Word became flesh so that we could believe, and God left us a written record for us to read. He planted faith among us, a tiny little seed. Buried like our uncle and father, all it takes now to raise from up under is to read and believe! I will not try to uproot you from the soil you know, recalling God’s creation: seed, sun and water—we reap what we sow; a man planted, a man watered, but it was God that kept making it grow.
Then God said,
“I’ve given you every sort of seed-bearing plant on Earth And every kind of fruit-bearing tree, given them to you for food. To all animals and all birds, everything that moves and breathes, I give whatever grows out of the ground for food.”
And there it was.
God looked over everything he had made; it was so good, so very good!
It was evening, it was morning—Day Six. — Genesis 1
“They were putting cannabinoid oil on the baby’s pacifier twice a day, increasing the dose… And within two months there was a dramatic reduction, enough that the pediatric oncologist allowed them to go ahead with not pursuing traditional therapy.”
New scientific studies suggest that getting high on marijuana can genuinely make you more creative.
Curran and Morgan are currently testing the effects of cannabis use on creativity in 400 subjects, and are then using neuroimaging technology to observe the neurobiological changes in the participants that are associated with creativity, while they are under the influence of cannabis.
“I think we’re dead—I really do.”
Anderson Cooper looks at the bizarre tendency of marijuana smokers to get themselves in trouble by calling 911.
Marijuana and Coffee are Good for the Brain discusses what happens to our brains as we age. Low doses of marijuana seem to stimulate the brain in positive ways. Coffee acts as another stimulant that is proving helpful. Professor Wenk also talks about the best method to slow down the aging process.
Do you know what will really keep you living and thinking clearly for a long time? Dr. Wenk does. His research explores the intersection of food and drugs and will challenge your biases on what makes a long life. His talk will explore why what we eat, and how much we eat, is the single most important daily decision we make that impacts how we age and how long we live.
Mary Jane Meets Tia Maria
As in Turkish coffee houses, or in bars of 16th century Amsterdam, this recipe has been a favorite for centuries.
- 300 milliliters (½ pint) hot fresh coffee
- 1-2 grams finely ground hash
- ½ teaspoon caster sugar
- 1 tablespoon of Tia Maria
Brew some fresh coffee and divide it into two cups. Add the sugar, liqueur and hashish to each. Top with whipped cream and dust in cocoa.
Recipe care of Good & Baked, “combining two of life’s sweetest pleasures”.
Selected Publications of Gary Wenk, professor of Psychology and Neuroscience at The Ohio State University
- Gold, P.E., Cahill, L., & Wenk, G.L. (2003) The lowdown on Ginkgo biloba. Scientific American, April, 86-91.PDF
- Doody, R.S., Mintzer, J.E., Sano, M., Wenk, G.L. & Grossberg, G.T. (2003) Alzheimer’s disease: Emerging noncholinergic treatments. Geriatrics, (Suppl) 3-11.
- Wenk, G.L. (2003) Neuropathologic changes in Alzheimer¹s Disease. Journal of Clinical Psychiatry, 64 (Suppl 9): 7-10. PDF
- Rogawski, M. & Wenk, G.L. (2003) The neuropharmacological basis for Memantine in the treatment of Alzheimer’s disease. CNS Drug Reviews, 9: 275-308. PDF
- Wenk, G.L., McGann-Gramling, K., Hauss-Wegrzyniak, B., Ronchetti, D., Maucci, R., Rosi, S., Gasparini, L. & Ongini, E. (2004) Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. Journal of Neurochemistry, 89: 484-493. PDF
- Wrenn, C.C., Kinney, J.W., Marriott, L.K., Holmes, A., Harris, A.P., Saavedra, M.C., Starosta, G., Innerfield, C.E., Jacoby, A.S., Shine, J., Iismaa, T.P., Wenk, G.L. & Crawley, J.N. (2004) Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor. European Journal of Neuroscience,19:1384-1396.
- Wenk, G.L. (2004) The role of BDNF and dopamine dysfunction in autism, In: M.L. Bauman & T.L. Kemper, (Eds.) The Neurobiology of Autism, 2nd Ed., The Johns Hopkins University Press, Baltimore, MD, pp. 362-370.
- Gasparini, L., Ongini, E. & Wenk, G.L. (2004) Non-steroidal anti-inflammatory drugs (NSAIDS) in Alzheimer’s disease: old and new mechanisms of action. Journal of Neurochemistry, 91: 521-536. PDF
- Mohmmad Abdul, H., Wenk, G.L., McGann-Gramling, K., Hauss-Wegrzyniak, B. & Butterfield, D.A. (2004) APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer’s disease. Neuroscience Letters, 368: 148-150. PDF
- Rosi, S., Ramirez-Amaya, V., Vazdarjanova, A., Worley, P.F., Barnes, C.A. & Wenk, G.L. (2005) Neuroinflammation alters selective patterns of behaviorally induced Arc expression in the hippocampus.Journal of Neuroscience, 25: 723-731. PDF
- Rosi, S., Pert, C.B., Ruff, M.R., McGann-Gramling, K. & Wenk, G.L. (2005) CCR5 chemokine receptor antagonist DAPTA reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer’s disease. Neuroscience, 134:671-676. PDF
- Rosi, S., Vazdarjanova, A., Ramirez-Amaya, V., Worley, P.F., Barnes, C.A. & Wenk, G.L. (2006) Memantine reduces the consequences of chronic neuroinflammation and restores the hippocampal pattern of behaviorally-induced Arc expression. Neuroscience, 142:1303-1315. PDF
- Wenk, G.L. (2006) Neuropathologic changes in Alzheimer’s disease: Potential targets for treatment. Journal of Clinical Psychiatry, 67:3-7. PDF
- Wenk, G.L., Parson, C. & Danysz, W. (2006) Potential role of NMDA receptors as executors of neurodegeneration resulting from diverse insults – focus on memantine. Behavioral Pharmacology 17: 411-424. PDF
- Marchalant, Y., Rosi, S. & Wenk, G.L. (2007) Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of Alzheimer’s disease. Neuroscience, 144:1516-1522. PDF
- Marchalant, Y., Cerbai, F., Brothers, H. & Wenk, G.L. (2008) Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats. Neurobiology of Aging, 29:1894-1901. PDF
- Wenk, G.L. & Marchalant, Y. (2009) Neuropharmacology. In: G.G. Berntson & J.T. Cacioppo, (Eds.) Handbook of Neuroscience for the Behavioral Sciences, John Wiley & Sons.
- Wenk, G.L. (2009) Neuroanatomy of learning and memory. In: D.S. Charney, E.J. Nestler, & B.S. Bunney, (Eds.) Neurobiology of Mental Illness, 3rd Ed., Oxford University Press, New York, NY.
- Marchalant,Y.,Brothers,H.M.,Norman,G.J.,Karolina,K.,DeVries, C. & Wenk, G.L. (2009) The differential role of endocannabinoid and vanilloid receptors in the control of neuroinflammation and neurogenesis in aged rats.Neurobiology of Disease, 34: 300-307. PDF
- Rosi, S., Ramirez-Amaya, V., Vazdarjanova, A., Esperanza, E., Larkin, P., Fike, J.R., Wenk, G.L. & Barnes, C.A. (2009) Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine. Brain, 132:2464-2468. PDF
- Marchalant, Y., Brothers, H.M. & Wenk, G. Wenk, (2009) Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain. Molecular Psychiatry, 14:1068-1071. PDF
- Brothers, H.M., Marchalant, Y., & Wenk, G. L. (2010) Caffeine attenuates lipopolysaccharide-induced neuroinflammation. Neuroscience Letters, 480:97-100. PDF
- Norman, G.J., Morris, J.S., Karelina, K., Weil, Z.M., Zhang, N., Al-Abed, Y., Brothers, H.M., Wenk, G.L., Pavlov, V.A., Tracey, K.J., DeVries, A.C., (2011) Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic ?7 nicotinic receptors. Journal of Neuroscience, 31:3446-3452.PDF
- Marchalant, Y., Baranger, K., Wenk, G.L., Khrestchatisky, M. & Rivera, S. (2012) Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention? Journal of Neuroinflammation PDF
- Bardou, I. DiPatrizio, N., Brothers, H.M., Kaercher, R.M., Baranger, K., Mitchem, M.R., Hopp, S.C., Wenk, G.L. & Marchalant, Y. (2012) Pharmacological manipulation of cannabinoid neurotransmission reduces neuroinflammation associated with normal aging. Health. PDF
- Cerbai, F., Lana, D., Nosi, D., Petkova-Kirova, P., Zecchi, S., Brothers, H., Wenk, G. L. & Giovannini, M.G. (2012) The neuron-astrocyte-microglia triad in normal brain aging and a model of neuroinflammation in the rat hippocampus. PlosOne PDF
When we are depressed our brains undergo many different biochemical changes; no one is quite certain which of these actually cause the typical feelings of sadness or hopelessness.
One important depression-related change is a dramatic decline in the birth of immature neurons, known as neurogenesis, in a brain region called the hippocampus.
Drugs that treat depression, such as Prozac and Zoloft, all induce a recovery in the rate of neurogenesis in the hippocampus.
So what’s the connection with marijuana and the munchies?
The drug, rimonabant, that was so successful in reducing food cravings as it induced depression and thoughts of suicide, has been recently shown (by Beyer and colleagues at Pfizer) to significantly reduce neurogenesis.
Let’s flip this idea on its side and ask, “What would happen to neurogenesis if we exposed the brain to marijuana?”
My lab investigated this idea and discovered that a small dose of marijuana, about only one puff, taken every day can reverse the age-related decline in neurogenesis that might underlie depression.
Whether this approach might also work in young people remains to be determined.
What these studies teach us is that our brain’s own marijuana neurotransmitter system is necessary for us to feel hungry, to experience happiness and to maintain the brain normal processes, such as neurogenesis, that prevent age-associated depression and cognitive decline.
We’ve learned from our experience with rimonabant that it is dangerous to constantly antagonize this neurotransmitter system.
What we do not know is whether it is dangerous to constantly stimulate it.