Ancestry, Cannabis

Genetic Variations in the Human Cannabinoid Receptor Gene Are Associated with Happiness

Abstract

Happiness has been viewed as a temporary emotional state (e.g., pleasure) and a relatively stable state of being happy (subjective happiness level).

As previous studies demonstrated that individuals with high subjective happiness level rated their current affective states more positively when they experience positive events, these two aspects of happiness are interrelated.

According to a recent neuroimaging study, the cytosine to thymine single-nucleotide polymorphism of the human cannabinoid receptor 1 gene is associated with sensitivity to positive emotional stimuli.

Thus, we hypothesized that our genetic traits, such as the human cannabinoid receptor 1 genotypes, are closely related to the two aspects of happiness.

In Experiment 1, 198 healthy volunteers were used to compare the subjective happiness level between cytosine allele carriers and thymine-thymine carriers of the human cannabinoid receptor 1 gene.

In Experiment 2, we used positron emission tomography with 20 healthy participants to compare the brain responses to positive emotional stimuli of cytosine allele carriers to that of thymine-thymine carriers.

Compared to thymine-thymine carriers, cytosine allele carriers have a higher subjective happiness level. Regression analysis indicated that the cytosine allele is significantly associated with subjective happiness level.

The positive mood after watching a positive film was significantly higher for the cytosine allele carriers compared to the thymine-thymine carriers.

Positive emotion-related brain region such as the medial prefrontal cortex was significantly activated when the cytosine allele carriers watched the positive film compared to the thymine-thymine carriers.

Thus, the human cannabinoid receptor 1 genotypes are closely related to two aspects of happiness. Compared to thymine-thymine carriers, the cytosine allele carriers of the human cannabinoid receptor 1 gene, who are sensitive to positive emotional stimuli, exhibited greater magnitude positive emotions when they experienced positive events and had a higher subjective happiness level.

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Governor McCrory signs Hope 4 Haley and Friends HB 1220
Cannabis

North Carolina Governor McCrory Signs “Hope 4 Haley & Friends” making CBD Oils Legal Treatment

Cannabis calms the excess electrical activity in young developing minds.

CBD RSHO (photo by Angela Glass)

In March, my husband Darryl and I took to the road to capture the stories of several North Carolina families hoping to treat their children with cannabis.

Most of the children we met suffered from debilitating epilepsy, then there are those with epilepsy and leukemia, and others with epilepsy and either ADD or autism or both. Continue reading

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Sherena and Haley Ward, the namesake of North Carolina's HB 1220: "Hope 4 Haley and Friends"
Cannabis

Hope 4 Haley and Friends—NC’s Push for Cannabis for Kids

In March, Darryl and I made a video interviewing North Carolina families with children who suffer from life threatening seizures who all want to bring CBD oil to North Carolina. That video made it to North Carolina Representative Pat McElraft who is working on “Hope for Haley”—for Haley who lives in her district.

State lawmakers last year defeated a bill that would have legalized “medical marijuana” in North Carolina. Continue reading

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Weed 2: Cannabis Madness (Dr. Sanjay Gupta, CNN 2014)
Cannabis

Weed 2: Gupta Doubles Down on Medical Marijuana

In the words of Dr. Sanjay Gupta, practicing neurosurgeon and CNN’s chief medical correspondent, “this scientific journey is about a growing number of patients who want the cannabis plant as a genuine medicine, not to get high.”

“It is about emerging science that not only shows and proves what marijuana can do for the body but provides better insights into the mechanisms of marijuana in the brain, helping us better understand a plant whose benefits have been documented for thousands of years. This journey is also about a Draconian system where politics override science and patients are caught in the middle.”

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Charlee Nelson dies, age 6.
Cannabis

Days after Charlee’s Law passes, Charlee Nelson dies at age 6

“She was in good enough shape to be there and be present. In the House when all the representatives stood up and gave her a round of applause, she perked up like she knew it was for her.”

Froerer said some representatives “really broke down” when they saw Charlee brought to the floor in a wheelchair.

Cannabis oil wouldn’t have cured Charlee, but it might have calmed her seizures and prolonged her life.

North Carolina children are fighting for the same treatment.

Sources:

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Kids for Cannabis with Epilepsy & Autism NC Map (Angela Glass 2014)
Cannabis

Kids for Cannabis

Darryl and I drove around North Carolina and interviewed these families about their experiences as parents of a child with epilepsy. These parents are fighting to be able to use cannabis as a treatment—several North Carolina families have moved to Colorado (for access to legal marijuana) with the children having great success.

#kidsforcannabis #kidswithcancer #kidswithepilepsy #kidswithautism #hope4kids #cannabis #THC #CBD

Update! See “Hope for Haley“.

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Marijuana Leaf Plays Epilepsy Cure Role, Salt Lake City Telegram May 20, 1949
Cannabis

1949 Salt Lake City Telegram: Marijuana Leaf Plays Epilepsy Cure Role

Marijuana Leaf Plays Epilepsy Cure Role, Salt Lake City Telegram May 20, 1949

Marijuana Leaf Plays Epilepsy Cure Role, Salt Lake City Telegram May 20, 1949

Reprint from Salt Lake City Telegram, May 20, 1949

Drug principles isolated from leaves of marijuana, an innocent-looking plant that grows wild in different parts of the world, are playing an important role in research on a cure for epilepsy.

This is the same marijuana which so many people fear as a habit-forming drug and which is noted for the opium-like dreams it produces in those who partake of it. Continue reading

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