Ancestry, Cannabis

Genetic Variations in the Human Cannabinoid Receptor Gene Are Associated with Happiness

Abstract

Happiness has been viewed as a temporary emotional state (e.g., pleasure) and a relatively stable state of being happy (subjective happiness level).

As previous studies demonstrated that individuals with high subjective happiness level rated their current affective states more positively when they experience positive events, these two aspects of happiness are interrelated.

According to a recent neuroimaging study, the cytosine to thymine single-nucleotide polymorphism of the human cannabinoid receptor 1 gene is associated with sensitivity to positive emotional stimuli.

Thus, we hypothesized that our genetic traits, such as the human cannabinoid receptor 1 genotypes, are closely related to the two aspects of happiness.

In Experiment 1, 198 healthy volunteers were used to compare the subjective happiness level between cytosine allele carriers and thymine-thymine carriers of the human cannabinoid receptor 1 gene.

In Experiment 2, we used positron emission tomography with 20 healthy participants to compare the brain responses to positive emotional stimuli of cytosine allele carriers to that of thymine-thymine carriers.

Compared to thymine-thymine carriers, cytosine allele carriers have a higher subjective happiness level. Regression analysis indicated that the cytosine allele is significantly associated with subjective happiness level.

The positive mood after watching a positive film was significantly higher for the cytosine allele carriers compared to the thymine-thymine carriers.

Positive emotion-related brain region such as the medial prefrontal cortex was significantly activated when the cytosine allele carriers watched the positive film compared to the thymine-thymine carriers.

Thus, the human cannabinoid receptor 1 genotypes are closely related to two aspects of happiness. Compared to thymine-thymine carriers, the cytosine allele carriers of the human cannabinoid receptor 1 gene, who are sensitive to positive emotional stimuli, exhibited greater magnitude positive emotions when they experienced positive events and had a higher subjective happiness level.

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Governor McCrory signs Hope 4 Haley and Friends HB 1220
Cannabis

North Carolina Governor McCrory Signs “Hope 4 Haley & Friends” making CBD Oils Legal Treatment

Cannabis calms the excess electrical activity in young developing minds.

CBD RSHO (photo by Angela Glass)

In March, my husband Darryl and I took to the road to capture the stories of several North Carolina families hoping to treat their children with cannabis.

Most of the children we met suffered from debilitating epilepsy, then there are those with epilepsy and leukemia, and others with epilepsy and either ADD or autism or both. Continue reading

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Sherena and Haley Ward, the namesake of North Carolina's HB 1220: "Hope 4 Haley and Friends"
Cannabis

Hope 4 Haley and Friends—NC’s Push for Cannabis for Kids

In March, Darryl and I made a video interviewing North Carolina families with children who suffer from life threatening seizures who all want to bring CBD oil to North Carolina. That video made it to North Carolina Representative Pat McElraft who is working on “Hope for Haley”—for Haley who lives in her district.

State lawmakers last year defeated a bill that would have legalized “medical marijuana” in North Carolina. Continue reading

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Weed 2: Cannabis Madness (Dr. Sanjay Gupta, CNN 2014)
Cannabis

Weed 2: Gupta Doubles Down on Medical Marijuana

In the words of Dr. Sanjay Gupta, practicing neurosurgeon and CNN’s chief medical correspondent, “this scientific journey is about a growing number of patients who want the cannabis plant as a genuine medicine, not to get high.”

“It is about emerging science that not only shows and proves what marijuana can do for the body but provides better insights into the mechanisms of marijuana in the brain, helping us better understand a plant whose benefits have been documented for thousands of years. This journey is also about a Draconian system where politics override science and patients are caught in the middle.”

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Charlee Nelson dies, age 6.
Cannabis

Days after Charlee’s Law passes, Charlee Nelson dies at age 6

“She was in good enough shape to be there and be present. In the House when all the representatives stood up and gave her a round of applause, she perked up like she knew it was for her.”

Froerer said some representatives “really broke down” when they saw Charlee brought to the floor in a wheelchair.

Cannabis oil wouldn’t have cured Charlee, but it might have calmed her seizures and prolonged her life.

North Carolina children are fighting for the same treatment.

Sources:

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Kids for Cannabis with Epilepsy & Autism NC Map (Angela Glass 2014)
Cannabis

Kids for Cannabis

Darryl and I drove around North Carolina and interviewed these families about their experiences as parents of a child with epilepsy. These parents are fighting to be able to use cannabis as a treatment—several North Carolina families have moved to Colorado (for access to legal marijuana) with the children having great success.

#kidsforcannabis #kidswithcancer #kidswithepilepsy #kidswithautism #hope4kids #cannabis #THC #CBD

Update! See “Hope for Haley“.

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Marijuana Leaf Plays Epilepsy Cure Role, Salt Lake City Telegram May 20, 1949
Cannabis

1949 Salt Lake City Telegram: Marijuana Leaf Plays Epilepsy Cure Role

Marijuana Leaf Plays Epilepsy Cure Role, Salt Lake City Telegram May 20, 1949

Marijuana Leaf Plays Epilepsy Cure Role, Salt Lake City Telegram May 20, 1949

Reprint from Salt Lake City Telegram, May 20, 1949

Drug principles isolated from leaves of marijuana, an innocent-looking plant that grows wild in different parts of the world, are playing an important role in research on a cure for epilepsy.

This is the same marijuana which so many people fear as a habit-forming drug and which is noted for the opium-like dreams it produces in those who partake of it. Continue reading

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Cannabis

Moving for Marijuana

Molly Grantham’s WBTV report on Medical Marijuana for North Carolina kids

Watch Charlotte’s WBTV report “Moving for Medical Marijuana“, “Mom’s Talk More…“, and “Inside the Grow” by reporter Molly Grantham.

Both Maria and Liz are two moms of roughly 150-200 nationwide who have their children on “Charlotte’s Web”, a natural cannabis treatment for, among other things, pediatric epilepsy.  Early success stories of families who have tried everything else and seen nothing work on their children’s epilepsy, say it could be a miracle drug.

But, it’s illegal in the Carolinas because it’s made from marijuana.

Both Maria and Liz moved with their children.  Both had to leave their husbands for their jobs.

“It comes from cannabis,” says Liz.  “But children don’t smoke it.  It’s a liquid medicine.  We give it to our children like other parents give Tylenol.  And most importantly, it only has trace amounts of THC.  You can’t get ‘high’ from taking Charlotte’s Web. Having tried it now and having had to move across country to get it, I honestly feel this is ridiculous we can’t have it everywhere.”

See also…

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Cannabis

PBS “Clearing the Smoke”: The Science of Cannabis

MontanaPBS’s new documentary, Clearing the Smoke, reveals how cannabis acts on the brain and in the body to treat nausea, pain, epilepsy and potentially even cancer. Extensive interviews with patients, doctors, researchers and skeptics detail the promises and the limitations of medicinal cannabis.

Renowned Cannabis Activist Dr. Lester Grinspoon

Renowned Cannabis Activist Dr. Lester Grinspoon featured in Clearing the Smoke: The Science of Cannabis (MontanaPBS)

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Cannabis,

Botany of Desire : Cannabis

Featuring Michael Pollan and based on his best-selling book, The Botany of Desire: A Plant’s-Eye View of the World, this special takes viewers on an eye-opening exploration of the human relationship with the plant world, seen from the plants’ point of view of four familiar species—the apple, the tulip, cannabis and the potato.

Watch Full-Length Program on PBS. See more from BOTANY OF DESIRE.

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Cannabis

NC Rep. Jones takes up case to legalize medical marijuana in some instances

By Molly Parker – Wilmington StarNews, originally published Jacksonville News: Monday, December 16, 2013 at 16:35 PM.

U.S. Rep. Walter Jones has taken up the case of a number of desperate North Carolina parents who are hoping state lawmakers will legalize medicinal marijuana for children with uncontrollable seizures. Continue reading

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Michael Saffioti
Cannabis, Ethics, Neuroscience

Michael Saffioti, 22, Dies in Overnight Jail

Michael Saffioti, 22, died in his cell at Snohomish County Jail last year after eating oatmeal that triggered his debilitating dairy allergy. His family claims in a lawsuit that guards ignored his calls for help and recklessly disregarded the seriousness of his condition.

Michael begged for help from his cell at Snohomish County Jail after eating some oatmeal that triggered his debilitating dairy allergy on July 2, 2012, but was ignored by guards until it was too late, a video obtained by local KIRO-7 TV shows.

The day before he died, Saffioti had turned himself into Lynnwood police for missing a court date on a misdemeanor pot bust.

Four months after Michael’s death recreational use was legalized in Washington state. Continue reading

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"We in Israel have an opportunity, and vast responsibility, when it comes to international research about medical cannabis. Israel has a government-sponsored medical cannabis program and a convenient regulatory climate for research. We also have the health maintenance organizations, which possess rare databases of precious information about the effects of cannabis on thousands of patients who have undergone that treatment.
Cannabis, Neuroscience

Conditions for Cannabis in Canaan

Governments and drug companies are loath to fund the research needed to bring the drug into general use—Israel offers ideal conditions for such research.

“We in Israel have an opportunity, and vast responsibility, when it comes to international research about medical cannabis. Israel has a government-sponsored medical cannabis program and a convenient regulatory climate for research. We also have the health maintenance organizations, which possess rare databases of precious information about the effects of cannabis on thousands of patients who have undergone that treatment.”—Mimi Peleg Continue reading

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Cannabis

Dr. Sanjay Gupta: "Sometimes marijuana is the only thing that works"

Dr. Sanjay Gupta says we have been “systematically misled” on marijuana… Take the case of Charlotte Figi, who he met in Colorado. She started having seizures soon after birth. By age 3, she was having 300 a week, despite being on seven different medications. Medical marijuana has calmed her brain, limiting her seizures to 2 or 3 per month.

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Cannabis

Marijuana—God’s Creation—in Forever, and Eternity

I wonder what God is going to do with marijuana in eternity.

Out of all humanity alive today, I wonder what percentage DOESN’T take a pharmaceutical prescription? Remember, someone dies in the United States every 19 minutes from a prescription drug overdose, mostly accidental.

God created marijuana, and Christ warned about *pharmakeia* in the last days (Revelation 9:21, 18:23, 21:8, 22:15; Galatians 5:19-22) as “sorcery” by which “all the nations were deceived”.

Sounds like the pharmaceutical industry, doesn’t it?

Certainly “all nations” aren’t going to be deceived by God’s own creation: “nor height nor depth **nor any other creation** will be able to separate us from God’s love that is in Christ Jesus our Lord.”

“For **the creation** was subjected to futility, not by its own will but through him that subjected it, on the basis of hope that the creation itself also will be set free from enslavement to corruption and have the glorious freedom of the children of God. For we know that **all creation** keeps on groaning together and being in pain together until now.”

God created coca leaves—coco leaves are soaked in gasoline and sulfuric acid to produce the substance cocaine.

My Peruvian acupuncturist had me chew coco leaves to adjust to altitude for the hike to Machu Picchu.

Even Sanjay Gupta, MD finally does research instead of simply following the crowd.

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Cannabis, Neuroscience

Carolina Parents Push for Medical Marijuana

By Molly.Parker@StarNewsOnline.com
Published: Saturday, September 21, 2013 at 10:00 p.m.
Matt and Annetta Saggese work on speech and physical therapy with their daughter Netta at their Wilmington home. Netta has intractable epilepsy and undergoes various therapies throughout the week. Her parents want her to have access to medical marijuana.

Matt and Annetta Saggese work on speech and physical therapy with their daughter Netta at their Wilmington home. Netta has intractable epilepsy and undergoes various therapies throughout the week. Her parents want her to have access to medical marijuana.

North Carolina parents of children who suffer severe seizures are lining up for access to and pushing for legalization of medical marijuana where it’s not already allowed.

They want people to know they’re not radicals. And they’re not going rogue. They are searching for options.

They freely admit they are desperate parents staring down nightmares with their children, having watched them develop early skills only to lose them at the hands of numerous seizures, only to have tried cocktails of medications with debilitating side effects and watch them not work.

They want the option legal in this state to try medical marijuana. They want it so they aren’t forced to uproot and move to another state where it’s legal, where there’s been early success in treating seizure disorders. Continue reading

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Cannabis

CBD Approved for Childhood Epilepsy Study

Orrin Devinsky MD, Director of the Comprehensive Epilepsy Center at New York University, was recently awarded FDA approval to conduct a clinical trial that will study the safety and tolerability of cannabidiol (CBD) in children with epilepsy.

“At this point, I think we really lack much data,” said Devinsky, who points to promising results in animals, but says the real push came from the anecdotal evidence provided by parents in Colorado.

“I’ve spoken with these parents, and I think they’re solid, good, loving parents, who’ve had very good experiences. Whether this will be borne out by scientific studies is uncertain,” he said.

Dr. Alan Shackelford oversaw the treatment of nine-month-old Kaitlyn Pogson’s Dravet syndrome, a type of epilepsy that causes her to have 300 seizures per week, administering high-CBD medical marijuana to the infant.

“The response was instantaneous,” Shackelford told the Star by telephone. “After the first dose, the seizures stopped … and she didn’t suffer a seizure for seven days.”

Charlotte now suffers one seizure every other week, Shackelford says, “a remarkable and heretofore unprecedented change.”

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"We in Israel have an opportunity, and vast responsibility, when it comes to international research about medical cannabis. Israel has a government-sponsored medical cannabis program and a convenient regulatory climate for research. We also have the health maintenance organizations, which possess rare databases of precious information about the effects of cannabis on thousands of patients who have undergone that treatment.
Cannabis, Neuroscience

The Quiet Giant: Israel’s Discreet and Successful Medicinal Cannabis Program

by Lindsay Stafford Mader, HerbalGram. 2013; American Botanical Council, Issue: 97 Page: 38-45

Despite its status as one of the world’s leading nations for medical research and innovation, the United States has a remarkably restrictive system in place to regulate medicinal cannabis research.

Even when the US Food and Drug Administration (FDA) approves medicinal cannabis studies, the researcher or institution must then obtain approval from the Public Health Service (PHS), as well as procure cannabis material from the National Institute on Drug Abuse (NIDA), which has a monopoly on the supply of cannabis that can be used for research throughout the entire country.1

Cannabis (Cannabis spp. Cannabaceae) is the only scheduled substance for which PHS approval is required, and those wishing to study the plant often have been rejected by the agency — effectively quelling this important area of science.

An increasing number of US states have taken matters into their own hands by legalizing medicinal cannabis for residents with certain health conditions.

But the federal government continues to raid and shut down state-based medicinal cannabis operations, even sending some of these business owners to prison.

Although the US situation is largely based on the discrepancy between state and federal law, Americans and citizens of other countries that ban medicinal cannabis could learn just how successfully, compassionately — and non-controversially — such a program can be handled by looking at the unique national medicinal cannabis program in Israel.

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Ancestry, Cannabis

Bubby

Randy at Hell's Point, Pokagon, Labor Day 2012

I am proud of my mother.

She challenged the authority when they told her that my uncle had six months to live.

In her heart, she knew better. In six weeks he was dead.

My mother didn’t fight the authority, there was no point. Either way, he’d be dead. Yet, my mother took her belief seriously. She rearranged her priorities, so that she could be with him not wanting to miss spending time with him while he still breathed.

My mother shared her belief with those of the family who would listen, and some believed what she, in faith, said. Because my mom is something of a natural nut, some chose to believe the word of the medical authority over what she so strongly believed.

My mother called us together, asking the family to gather, to spend time with him. The doctors had decreed his six months in July, my mom come and see him Memorial Day. I questioned my mother, asked her, is it Labor Day you mean? More than her words, I knew what she meant, what her belief would mean.

Schaadt's in Hell

Those of who believed, who took the health nut my momma seriously, took heed. The family all gathered, and the other side of the family hosted, the ones who take my mom seriously. Amid music and singing, children playing and sunflowers, my aunt and uncle (of that side of the family) offered Uncle Randy relief in the form of a weed. Though it’s not an appropriate natural remedy in my mother’s belief, it was thanks to God’s creation that he was able to join in the merriment, raising a guitar to his knee. Before that day, I never he knew that he could really play.

Uncle Randy

Later I confessed to my mother that she must know that the pleasure thanks to the leaves of a weed. I urged her to urge his caregiver to implore his doctor to prescribe him the prescription, mans form of God’s gift by the hand of their own authority. My aunt, the caregiver, and my mother agreed, though the need was plain to see, relief shouldn’t be obtained in the form of what they’d call “weed“, they apparently don’t approve whether relief is by a pill form prescription or by what he’d breath, or eat. I’d never make it home fast enough to see about sending him cookies.

That was the last day I’d really see him, that day watching the last of his life—more so than any other day I’d ever seen—as he laughed and he played and he drank and even sang. That night, still relieved, apparently was the last and only he’d really sleep. Later I here he spent hours dead to the world, but even a caregiver, I imagine if I am bold, will note the difference between succumbing to death and breathing easy in sleep.

All this is to say, that I’m proud of my mother and that though they’d say that he’d have six months in this life to remain. My mother, though others would think her insane, ignored the authority and in her campaign we thus would win the last few days we’d never get back again. Those who’d doubt totally missed out, but my mother made sure we had all the time with him that we could spend.

I think of my mother happy that she’d challenge authority. What they said she simply couldn’t believe. They say that ‘faith is the assured expectation of things not yet beheld’, and it takes faith to believe.

Had my mother held to her faith, and urged us to believe, I wouldn’t have seen my uncle and get to say goodbye, in not so many words, before he’d leave.

My dear parents, my sisters and my brother, I’m glad we all listened to our mother, listened to her, trusted, had faith and believed—even though we weren’t raised to question authority.

Momma didn’t try to fight the authority, and neither will I.

Momma at the Lake, Labor Day 2012

I believe that we’ll all obtain life, given the lives we live, when we die. The difference is simply the reward you’ll obtain, by what words we heed while in this life we remain. I think of Nikki, who momma’s words didn’t heed, she heard but didn’t listen, and by doubt missed out because it was the doctor’s she chose to believe. She said she’d see him later, and though in this life she was wrong, I imagine that one day the band will get back together, and we all will be there to sing along.

Grandpa, Me, and Uncle Randy

I hope that you’ll respect me, as I take my leave from believing what I was taught is the authority. I asked them questions they couldn’t answer, so I’ll believe what I read. The Word became flesh so that we could believe, and God left us a written record for us to read. He planted faith among us, a tiny little seed. Buried like our uncle and father, all it takes now to raise from up under is to read and believe! I will not try to uproot you from the soil you know, recalling God’s creation: seed, sun and water—we reap what we sow; a man planted, a man watered, but it was God that kept making it grow.

Then God said,

“I’ve given you every sort of seed-bearing plant on Earth And every kind of fruit-bearing tree, given them to you for food. To all animals and all birds, everything that moves and breathes, I give whatever grows out of the ground for food.”

And there it was.

God looked over everything he had made; it was so good, so very good!

It was evening, it was morning—Day Six. — Genesis 1

 

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Cannabis, Neuroscience, Psychology

Does Cannabis Boost Creativity?

Santa Cruz student explores her imagination and cultivates creative thought with the help of her favorite herb. Credit: David Jay Brown.

Does Cannabis Boost Creativity?

New scientific studies suggest that getting high on marijuana can genuinely make you more creative.

Curran and Morgan are currently testing the effects of cannabis use on creativity in 400 subjects, and are then using neuroimaging technology to observe the neurobiological changes in the participants that are associated with creativity, while they are under the influence of cannabis.

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Cannabis, Neuroscience

Diagnosis!

From: Angela M. Baxley
Date: May 18, 2011 1:19:46 AM EDT
To: BAY
Subject: Diagnosis!

I have a diagnosis: hyperthymic temperament with [drug induced episodes of] hypomania.

Talked to a doctor today (see below). We talked for a little more than an hour, over the phone. He ruled out epilepsy (if a concern, past as childhood) and manic/bipolar, depression.

He said there isn’t much a treatment. Continue Serofin, likely that can reduce “need” for effects of MJ. Should know in about 1 month.

Half-life for Clonazepam is extremely long and he was not at all surprised by any of my experiences.

Apparently I’ll just live with hypothymic [sic] temperament the same way Micheal just lives with dysphoria. I’m the euphoria to his dysphoria. No wonder I was so attracted to him. I always felt he gave me that other half of life perspective.

@ang @baxley

 


 

Begin forwarded message:

From: “Vishaal Mehra”
Date: May 16, 2011 3:56:03 PM PDT
To: “‘Angela M. Baxley'”
Subject: RE: Request

Hi Angela

Clonazepam (and other benzodiazepine medication) can have an atypical response in some individuals, such as disinhibition, mood changes, and activation—rather than the expected calming/sedation often seen with these types of meds.

Would you like to talk over the phone to discuss your symptoms further?

I have some availability this week

Let me know

Vishaal

Vishaal Mehra MD, CPI
CEO and Medical Director
Artemis Institute for Clinical Research
8787 Complex Dr, Ste 100
San Diego, CA 92123
Office: (858) ARTEMIS (278-3647)

 


 

From: Angela M. Baxley
Sent: Monday, May 16, 2011 3:35 PM
To: Vishaal Mehra
Subject: Re: Request

Hi Vishaal,

Thank you for helping. Matt is a great guy, and I appreciate all his help as well.

I have had unusual symptoms from what I can recall around 15 or so up to today. I would like to see who might be able to professionally guide my search for understanding.

I recently had a panic attack with which I took 2 Clonazepam. That sent me into a rage. That sent me to Wikipedia, where I learned that much of what’s been “wrong” may all be due to the medication.

Please let me know what you need from me.

And once again,
Thank you.

Angela

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