I nibbled a bit of Microsoft, and a byte of Apple.
Interview with Steve Jobs and Bill Gates at D7 (2007)
Q: “…personally come in every day to save it…?
A: “…that’s my life’s work…”
As previous studies demonstrated that individuals with high subjective happiness level rated their current affective states more positively when they experience positive events, these two aspects of happiness are interrelated.
According to a recent neuroimaging study, the cytosine to thymine single-nucleotide polymorphism of the human cannabinoid receptor 1 gene is associated with sensitivity to positive emotional stimuli.
Thus, we hypothesized that our genetic traits, such as the human cannabinoid receptor 1 genotypes, are closely related to the two aspects of happiness.
In Experiment 1, 198 healthy volunteers were used to compare the subjective happiness level between cytosine allele carriers and thymine-thymine carriers of the human cannabinoid receptor 1 gene.
In Experiment 2, we used positron emission tomography with 20 healthy participants to compare the brain responses to positive emotional stimuli of cytosine allele carriers to that of thymine-thymine carriers.
Compared to thymine-thymine carriers, cytosine allele carriers have a higher subjective happiness level. Regression analysis indicated that the cytosine allele is significantly associated with subjective happiness level.
The positive mood after watching a positive film was significantly higher for the cytosine allele carriers compared to the thymine-thymine carriers.
Positive emotion-related brain region such as the medial prefrontal cortex was significantly activated when the cytosine allele carriers watched the positive film compared to the thymine-thymine carriers.
Thus, the human cannabinoid receptor 1 genotypes are closely related to two aspects of happiness. Compared to thymine-thymine carriers, the cytosine allele carriers of the human cannabinoid receptor 1 gene, who are sensitive to positive emotional stimuli, exhibited greater magnitude positive emotions when they experienced positive events and had a higher subjective happiness level.
“What will happen to life when science identifies the genetic basis of happiness? Who will own the patent? Do we dare revise our own temperaments?…”
I once met a physics teacher who immediately recognized me as the main character in the play he was nearly finished writing.
Born to Be Happy
After reading an article “Born to Be Happy“, I found myself emailing Hagop Akiskal, M.D., Professor of Psychiatry and Director of the International Mood Center at the University of California at San Diego whose “work on dysthymia, cyclothymia and hyperthymia challenged the concept of personality disorders, led to the development of a new instrument (Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS-A)), thereby contributing to the worldwide renaissance of the temperament field.”
“Information may travel at light speed, but meaning spreads at the speed of dark.”
But being told that I was “hard wired for happiness” seemed a bit over simplified and “hard wired” seemed an insult to this interaction-designer-wannabe-cognitive scientist studying neurogenesis and neuroplasticity.
On “Rewiring the Real“
“Digital and electronic technologies that act as extensions of our bodies and minds are changing how we live, think, act, and write. Some welcome these developments as bringing humans closer to unified consciousness and eternal life. Others worry that invasive globalized technologies threaten to destroy the self and the world. Whether feared or desired, these innovations provoke emotions that have long fueled the religious imagination, suggesting the presence of a latent spirituality in an era mistakenly deemed secular and post-human.”
- Only occurs on earth as the result of the radioactive decay of other elements, like Uranium and Thorium.
- Most stable isotope has a half life of only 8 hours
- Can’t be seen with a naked eye, because any mass big enough for you to see would…
- Vaporize itself and maybe you and everything around you by the heat generated by it’s own radioactivity.
- Vaporize cancer. Precise in awe inspiring destruction.
Targeted alpha therapy.
Oh, never mind the perfect water system. It’s no big deal. 😉
Validated Criteria for Clinician-Rated Trait Hyperthymia. Primary Psychology (2004)
Hyperthymia is characterized by four or more of the following attributes, which are not episode-bound, and constitute part of the habitual long-term functioning of the individual
- Upbeat and exuberant
- Articulate and jocular
- Over-optimistic and carefree
- Over-confident and boastful
- High energy level, full of plans and improvident activities
- Versatile, with broad interests
- Over-involved and meddlesome
- Uninhibited and risk-taking
- Short sleeper (<6 hours/night)
“Light, both natural and artificial, is a powerful cue for the circadian clock, the internal timing device that tells us when to wake up and go to sleep, when to eat, and when we are most mentally alert. Continue reading
The Hyperthymic Temperament
Posted on 18 December, 2011, Read more at Molly.com…
The Thymus Gland is located by the breastbone in the nook between our throat and shoulders. A small gland, at risk as our sensitive neck and spine adjust to the ever-shifting weight of our skulls.
The Thymus, throughout history, has been a bit mysterious. It is believed to be a part of human/primate immunity and behavioral posturing.
Imagine male Gorillas pounding their chests. It’s thought that gorillas don’t only posture, but stimulate a specific biological response – to excite or to calm – by pounding upon their prominent Thymus glands.
While it is true that patients who experience hypomania as a side effect of Clonazepam may prove to have a form of bipolar disorder that has previously gone unrecognized, drug-induced hypomania is not invariably indicative of bipolar affective disorders.
It’s frustrating because suddenly I’m facing the woes I wrote about in college regarding labeling mental illness, and the impact of the use of labels, such as “creative” or “over-achiever”.
- I am hyperthymic, literally, “over spirited”.
- It’s not a diagnosis, because being “consistently happy” is not recognized as a mood disorder.
- I became hypomanic, but that wasn’t exhibiting hidden underlying bipolar or schizophrenic disorder.
- It’s not bipolar… it’s drug induced paradoxical side effects.
Label it or Leave it?
Some people would include in the Bipolar Disorder category a consistently elevated mood called hyperthymia. Being constantly upbeat and always enthusiastic is not unheard of, but it is not the norm in the general population. It is more common to experience a fairly steady, neither-too-high-nor-too-low mood characterized by some contentment, some discontentment, some happiness, and some sadness — usually associated with external events such as receiving good news, problems with personal relationships, etc.
Does a long-lasting, exuberant mood that causes no problem need to be placed on the spectrum of mood disorders? In a clinical sense, no. If it poses no threat to anyone’s health, it is not a concern for psychiatrists. Cataloging and understanding a mental state like this, however, may help us better understand the full spectrum of emotional states related to mood disorders and provide clues about what can go wrong when moods become extreme.
Some people always seem to be upbeat and energetic, trying new things and initiating new projects. This trait, which is sometimes called hyperthymia, is not unlike being on a “permanent high.” Some people argue that hyperthymia is a type of mood disorder that results in high activity and inflated sense of self-esteem — something like living with constant hypomania but with the crucial difference that it is not as clearly episodic. Instead, it seems to last and is without any associated depression.
While observations of many people indicate some of them have this mood trait, hyperthymic disorder is not recognized as a mood disorder by either of the two mainstream authorities, the American Psychiatric Association and the World Health Organization. It appears in neither of their diagnostic manuals, the DSM IV and the ICD-10.
On the surface, people with hyperthymia seem optimistic and full of energy. They radiate self-confidence and self-reliance; they seem to believe they can do whatever needs to be done. They thrive on new experiences that promise variety, intrigue, and novelty. Usually, they have a great many personal interests, as well as plans for the future. They also can be articulate and witty.
It might be most accurate to think of hyperthymia as a temperament or personality trait rather than as a marker of a mental disorder. Of course, if this trait causes problems, then it becomes a legitimate subject for psychological or psychiatric care.
In fact, criticism of mainstream psychiatry is often directed at its alleged predisposition to label people with problems that don’t exist. The inclusion of homosexuality in earlier editions of the DSM IV — an error since corrected — is a frequently cited example. The reality is if someone is not unhappy, suffering, or a threat to themselves or others, psychiatrists have no reason to intervene. They are busy enough treating people with serious mental problems. It is only when complaints or serious problems appear that the labels of the DSM IV are applied as part of the process for providing effective treatment. A hyperthymic personality can be satisfying, productive, and creative. But if for some individuals it is a manifestation of a part of a spectrum of mood disorders, it could be problematic. For example, some people later diagnosed with bipolar disorder first seek help with depression after they have experienced a set-back in their lives. A close look back over their lives may reveal that they have been hyperthymic. Rather than having easily recognizable mood swings, these people may have been experiencing years of constant emotional elevation and enthusiasm along with a long history of uncompleted endeavors.
Also, the lack of a healthy response to the full range of life experience might cause problems for some people who always seem to have elevated spirits. A full, healthy life for most people includes periods of elation and introspection, action and reflection. If only one pole of our emotional lives is present, we may miss the benefits of the counterbalancing half of our responses to events. Consequently, we may lack understanding and empathy in the way we interact with people and respond to events in our lives.
“I know, you’re bi-polar.”
“Old man, look at my life, I’m a lot like you were.”
Born to Be Happy, Through a Twist of Human Hard Wire
By RICHARD A. FRIEDMAN, M.D.
In the course of the last year, the woman lost her husband to cancer and then her job. But she did not come to my office as a patient; she sought advice about her teenage son who was having trouble dealing with his father’s death.
Despite crushing loss and stress, she was not at all depressed – sad, yes, but still upbeat. I found myself stunned by her resilience. What accounted for her ability to weather such sorrow with buoyant optimism? So I asked her directly.
“All my life,” she recalled recently, “I’ve been happy for no good reason. It’s just my nature, I guess.”
But it was more than that. She was a happy extrovert, full of energy and enthusiasm who was indefatigably sociable. And she could get by with five or six hours of sleep each night.
Like this woman, a journalist I know realized when she was a teenager that she was different from others. “It’s actually kind of embarrassing to be so cheerful and happy all the time,” she said. “When I was in high school I read the Robert Browning poem `My Last Duchess.’ In it, the narrator said he killed his wife, the duchess, because, `she had a heart – how shall I say, too soon made glad?’ And I thought, uh-oh, that’s me.”
These two women were lucky to be born with a joyous temperament, which in its most extreme forms is called hyperthymia. Cheerful despite life’s misfortunes, energetic and productive, they are often the envy of all who know them because they don’t even have to work at it.
In a sense, they are the psychiatric mirror image of people who suffer from a chronic, often lifelong, mild depression called dysthymia, which affects about 3 percent of American adults. Always down, dysthymics experience little pleasure and battle through life with a dreary pessimism. Despite whatever fortune comes their way, they remain glum.
But hyperthymia certainly doesn’t look like an illness; there appears to be no disadvantage to being a euphoric extrovert, except, perhaps, for inspiring an occasional homicidal impulse from jealous friends or peers. But little is actually known about people with hyperthymia for the simple reason that they don’t see psychiatrists complaining that they are happy.
I was talking with my momma this morning about orthomolecular medicine, and all the work she’s done to help people achieve better health over the years. Most often when I’m thinking about my momma in this regard, I think of how it is that she’s responsible for bringing life to families struggling to have children. What more beautiful work can there be as a humanitarian than to care for the quality of human life, and it’s propagation through it’s generations of families? Continue reading
Sometimes in this business you are called upon to treat a madman, or a madwoman, someone seemingly psychotic, talking way over your head, out there, but still oriented times three (person, place, time). You sense genius. You feel that this person is smarter than you are, or at least as smart.
You recognize, right away, undeniable talent and intellect. He is a song-writer, a one-hit wonder. She is an artist. He is a poet; she directs a television show. He is a computer programmer; she is a doctor. And you’re humble. You go home and think, why in the world see me?
But you know why. The patient needs your particular genius, because his madness is getting in the way. Others are complaining, complaining so loudly, you can hear them and they’re not in the room, not even in the building. You suspect mental illness.
And it usually is. Nassir Ghaemi, author of A First-Rate Madness: Uncovering the Links Between Leadership and Mental Illness, is of the opinion that it isn’t always so bad. Indeed, some creative people have a hyperthymic temperament. They rarely need therapy, not unless no one else will listen to them. It is not a disorder.— therapydoc is at gmaildotcom
“Many people who experience traumas [like terrorism or war] don’t develop PTSD or other illnesses. So the question is, what keeps those people from getting sick? What creates resilience?
The psychological research suggests that personality is a major factor.
Resilience seems to be associated with mild manic symptoms, but you can’t develop resilience unless you’ve already experienced trauma.
Many of these leaders faced adversity in their childhood and adulthood, and that seemed to make them better able to handle crises. It’s like a vaccine.
You get exposed to a little bit of a bacteria then you can handle major infections and I think trauma and resilience and hyperthymic personality seem to follow a similar path.”
Psychiatrist Nassir Ghaemi believes that mental illness can foster great leadership, but the Republican presidential candidates are too “normal.” (06:54)
The Colbert Report
Ghaemi: “Mild manic symptoms through-out ones life psychiatrists call ‘hyperthymic personality’.”
Colbert: “Sounds like a mad scientist.
Ghaemi: “One of the things about mania is that it does cause a person to have many different kinds of thoughts, many of which are creative. Connections happen because the thoughts are fast and in different directions in a way that mentally healthy average people do not have.”
Colbert: “Which of them do you think seems the most—creative?”
Ghaemi: “I have to say, you ask just the right question. That’s what we should be asking about our leaders. Who are creative, resilient, empathic and realistic? These are the four traits of leadership that grow out of mania and depression. And if we ask those questions we’ll get people like that—Colbert interjects, “Who?”—and we should accept them.
Colbert: “No Drama Obama” — “One way to get a better leader in office is to gaslight them and to make them crazy—I mean, the tea party could be therapy.”
Colbert: “You’re born with this—It’s genetic?”
Colbert: “Perhaps we should have cheek scrapings for these—or a reserve President…”
Ghaemi: “…some abnormality is actually quite good.”
“It is no measure of health to be well adjusted to a profoundly sick society.”—J. Krishnamurti
In July 2011, I spent a total of nine days in the San Diego County Psychiatric Hospital. Being sane in an insane place is much harder than you might think, but then again maybe you don’t think I’m sane.*
I know how the caged bird sings, she sings with resonation found only on the super slick floors that only an insane asylum can afford where she sings “Crazy“.
“How do we know precisely what constitutes “normality” or mental illness? Conventional wisdom suggests that specially trained professionals have the ability to make reasonably accurate diagnoses. What is—or is not—“normal” may have much to do with the labels that are applied to people in particular settings.”
The Rosenhan Experiment
The Rosenhan experiment was a famous experiment into the validity of psychiatric diagnosis conducted by psychologist David Rosenhan in 1973. It was published in the journal Science under the title “On Being Sane in Insane Places.” Rosenhan DL (January 1973). The study is considered an important and influential criticism of psychiatric diagnosis. Lauren Slater later revisits the experiment and publishes her findings in Opening Skinner’s Box: Great Psychological Experiments of the Twentieth Century (2004).
Hagop Akiskal MD of UCSD, favors the term, “hyperthymic,” a temperament opposite to “depressive.” Dr Akiskal views temperament as coexisting on the same spectrum with illness, ranging from advantageous to pathological.
The DSM views hypomania as an “episode” that is part of bipolar disorder, but, unlike depression, it is not considered an illness in its own right. People may act a bit strange when hypomanic, but they tend to be able to hold onto their jobs and personal relationships. Indeed, when hypomanic our productivity and creativity and sociability tend to make us the envy of the rest of the world.
Individuals with a hyperthymic personality disorders are persistently more happy and optimistic than normal.
They have marked enthusiasm for life but on the other hand tend to be rash and show poor judgement.
Link: Hyperthymic Personality
Now, the better question would be, what if there is no depression? Can people just have mild mania? And the answer to that is at one level it appears that God or nature or Darwin or whoever evolved our brains or created our brains did it in such a way that it doesn’t seem that episodic, mild mania can happen by itself. It has not really been described that people can have intermittent hypomania and nothing else, no depression. It can happen, but it’s probably rare. Just having manic episodes without depressive episodes is reported in maybe 5 to 10 percent of bipolar patients, and we don’t really know if just having hypomanic episodes can happen.
Trying to capture all my thoughts is exhausting but seems necessary in my creative process. The connections I see forming, as I let my thoughts go rather than trying to focus them, are astounding. Continue reading
From: Angela M. Baxley
Date: May 18, 2011 1:19:46 AM EDT
Talked to a doctor today (see below). We talked for a little more than an hour, over the phone. He ruled out epilepsy (if a concern, past as childhood) and manic/bipolar, depression.
He said there isn’t much a treatment. Continue Serofin, likely that can reduce “need” for effects of MJ. Should know in about 1 month.
Half-life for Clonazepam is extremely long and he was not at all surprised by any of my experiences.
Apparently I’ll just live with hypothymic [sic] temperament the same way Micheal just lives with dysphoria. I’m the euphoria to his dysphoria. No wonder I was so attracted to him. I always felt he gave me that other half of life perspective.
Begin forwarded message:
From: “Vishaal Mehra”
Date: May 16, 2011 3:56:03 PM PDT
To: “‘Angela M. Baxley'”
Subject: RE: Request
Clonazepam (and other benzodiazepine medication) can have an atypical response in some individuals, such as disinhibition, mood changes, and activation—rather than the expected calming/sedation often seen with these types of meds.
Would you like to talk over the phone to discuss your symptoms further?
I have some availability this week
Let me know
Vishaal Mehra MD, CPI
CEO and Medical Director
Artemis Institute for Clinical Research
8787 Complex Dr, Ste 100
San Diego, CA 92123
Office: (858) ARTEMIS (278-3647)
From: Angela M. Baxley
Sent: Monday, May 16, 2011 3:35 PM
To: Vishaal Mehra
Subject: Re: Request
Thank you for helping. Matt is a great guy, and I appreciate all his help as well.
I have had unusual symptoms from what I can recall around 15 or so up to today. I would like to see who might be able to professionally guide my search for understanding.
Please let me know what you need from me.
And once again,