Sherena and Haley Ward, the namesake of North Carolina's HB 1220: "Hope 4 Haley and Friends"
Cannabis

Hope 4 Haley and Friends—NC’s Push for Cannabis for Kids

In March, Darryl and I made a video interviewing North Carolina families with children who suffer from life threatening seizures who all want to bring CBD oil to North Carolina. That video made it to North Carolina Representative Pat McElraft who is working on “Hope for Haley”—for Haley who lives in her district.

State lawmakers last year defeated a bill that would have legalized “medical marijuana” in North Carolina. Continue reading

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Kids for Cannabis with Epilepsy & Autism NC Map (Angela Glass 2014)
Cannabis

Kids for Cannabis

Darryl and I drove around North Carolina and interviewed these families about their experiences as parents of a child with epilepsy. These parents are fighting to be able to use cannabis as a treatment—several North Carolina families have moved to Colorado (for access to legal marijuana) with the children having great success.

#kidsforcannabis #kidswithcancer #kidswithepilepsy #kidswithautism #hope4kids #cannabis #THC #CBD

Update! See “Hope for Haley“.

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Marijuana Leaf Plays Epilepsy Cure Role, Salt Lake City Telegram May 20, 1949
Cannabis

1949 Salt Lake City Telegram: Marijuana Leaf Plays Epilepsy Cure Role

Marijuana Leaf Plays Epilepsy Cure Role, Salt Lake City Telegram May 20, 1949

Marijuana Leaf Plays Epilepsy Cure Role, Salt Lake City Telegram May 20, 1949

Reprint from Salt Lake City Telegram, May 20, 1949

Drug principles isolated from leaves of marijuana, an innocent-looking plant that grows wild in different parts of the world, are playing an important role in research on a cure for epilepsy.

This is the same marijuana which so many people fear as a habit-forming drug and which is noted for the opium-like dreams it produces in those who partake of it. Continue reading

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Cannabis

Montgomery of Phoenix Forces Child to Eat Marijuana

While families across the United States are broken as a mother and child move to Colorado, from their home states where medical marijuana is not legal, for non-psychoactive high CBD oil anecdotally proven to stop seizures, an Arizona family is being harassed by local state officials and Maricopa County Attorney William Montgomery…

The Welton family received a medical marijuana card from the state for their son Zander in September and began treatment with cannabidiol (high CBD oil) with great results. Continue reading

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Cannabis

Minnesota Moms Move for Medical Marijuana

Gretta and her mom, a nurse, Maria. Photo by Kare.

“If you would have asked me a year ago if I would have had my daughter on marijuana I would have thought you were crazy. I mean, really?” said Maria Botker. “But when you have put your daughter through something as scary as brain surgery like we did with Greta about three years ago, this seems like nothing, really nothing.”

Continue reading

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Cannabis

Moving for Marijuana

Molly Grantham’s WBTV report on Medical Marijuana for North Carolina kids

Watch Charlotte’s WBTV report “Moving for Medical Marijuana“, “Mom’s Talk More…“, and “Inside the Grow” by reporter Molly Grantham.

Both Maria and Liz are two moms of roughly 150-200 nationwide who have their children on “Charlotte’s Web”, a natural cannabis treatment for, among other things, pediatric epilepsy.  Early success stories of families who have tried everything else and seen nothing work on their children’s epilepsy, say it could be a miracle drug.

But, it’s illegal in the Carolinas because it’s made from marijuana.

Both Maria and Liz moved with their children.  Both had to leave their husbands for their jobs.

“It comes from cannabis,” says Liz.  “But children don’t smoke it.  It’s a liquid medicine.  We give it to our children like other parents give Tylenol.  And most importantly, it only has trace amounts of THC.  You can’t get ‘high’ from taking Charlotte’s Web. Having tried it now and having had to move across country to get it, I honestly feel this is ridiculous we can’t have it everywhere.”

See also…

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Cannabis

PBS “Clearing the Smoke”: The Science of Cannabis

MontanaPBS’s new documentary, Clearing the Smoke, reveals how cannabis acts on the brain and in the body to treat nausea, pain, epilepsy and potentially even cancer. Extensive interviews with patients, doctors, researchers and skeptics detail the promises and the limitations of medicinal cannabis.

Renowned Cannabis Activist Dr. Lester Grinspoon

Renowned Cannabis Activist Dr. Lester Grinspoon featured in Clearing the Smoke: The Science of Cannabis (MontanaPBS)

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Cannabis, Neuroscience

Survey of Kids and Cannabis

Photo by CNN.

84% of the parents surveyed reported a reduction in their child’s seizure frequency while taking cannabidiol-enriched cannabis.

Severe childhood epilepsies are characterized by frequent seizures, neurodevelopmental delays, and impaired quality of life. In these treatment-resistant epilepsies, families often seek alternative treatments.

In the December 2013 issue of the journal Epilepsy and Behavior, Drs. Porter and Jacobsen from Stanford University investigate the use of cannabidiol-enriched cannabis in children with treatment-resistant epilepsy.

The survey was presented to parents belonging to a Facebook group dedicated to sharing information about the use of cannabidiol-enriched cannabis to treat their child’s seizures.

Nineteen responses met the following inclusion criteria for the study: a diagnosis of epilepsy and current use of cannabidiol-enriched cannabis.

Thirteen children had Dravet syndrome, four had Doose syndrome, and one each had Lennox–Gastaut syndrome and idiopathic epilepsy.

The average number of antiepileptic drugs (AEDs) tried before using cannabidiol-enriched cannabis was 12.

  • Sixteen (84%) of the 19 parents reported a reduction in their child’s seizure frequency while taking cannabidiol-enriched cannabis.
    • Of these, two (11%) reported complete seizure freedom
    • eight (42%) reported a greater than 80% reduction in seizure frequency
    • six (32%) reported a 25-60% seizure reduction.
  • Other beneficial effects included increased alertness, better mood, and improved sleep.
  • Side effects included drowsiness and fatigue.

The survey shows that parents are using cannabidiol-enriched cannabis as a treatment for their children with treatment-resistant epilepsy.

Calming Jayden’s Seizures from Ariana van den Akker on Vimeo.

Because of the increasing number of states that allow access to medical cannabis, its use will likely be a growing concern for the epilepsy community. Safety and tolerability data for cannabidiol-enriched cannabis use among children are not available.

Objective measurements of a standardized preparation of pure cannabidiol are needed to determine whether it is safe, well tolerated, and efficacious at controlling seizures in this pediatric population with difficult-to-treat seizures.

Keywords: Cannabidiol, Dravet syndrome, Epilepsy, Intractable, Medically refractory seizures, Pediatric, Side effects, Treatment-resistant

Brenda E. Porter, Catherine Jacobson, Epilepsy & Behavior, Volume 29, Issue 3, December 2013, Pages 574-577, ISSN 1525-5050, http://dx.doi.org/10.1016/j.yebeh.2013.08.037. (http://www.sciencedirect.com/science/article/pii/S1525505013004629)

Photo by CNN.

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Cannabis,

Botany of Desire : Cannabis

Featuring Michael Pollan and based on his best-selling book, The Botany of Desire: A Plant’s-Eye View of the World, this special takes viewers on an eye-opening exploration of the human relationship with the plant world, seen from the plants’ point of view of four familiar species—the apple, the tulip, cannabis and the potato.

Watch Full-Length Program on PBS. See more from BOTANY OF DESIRE.

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Michael Saffioti
Cannabis, Ethics, Neuroscience

Michael Saffioti, 22, Dies in Overnight Jail

Michael Saffioti, 22, died in his cell at Snohomish County Jail last year after eating oatmeal that triggered his debilitating dairy allergy. His family claims in a lawsuit that guards ignored his calls for help and recklessly disregarded the seriousness of his condition.

Michael begged for help from his cell at Snohomish County Jail after eating some oatmeal that triggered his debilitating dairy allergy on July 2, 2012, but was ignored by guards until it was too late, a video obtained by local KIRO-7 TV shows.

The day before he died, Saffioti had turned himself into Lynnwood police for missing a court date on a misdemeanor pot bust.

Four months after Michael’s death recreational use was legalized in Washington state. Continue reading

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"We in Israel have an opportunity, and vast responsibility, when it comes to international research about medical cannabis. Israel has a government-sponsored medical cannabis program and a convenient regulatory climate for research. We also have the health maintenance organizations, which possess rare databases of precious information about the effects of cannabis on thousands of patients who have undergone that treatment.
Cannabis, Neuroscience

Conditions for Cannabis in Canaan

Governments and drug companies are loath to fund the research needed to bring the drug into general use—Israel offers ideal conditions for such research.

“We in Israel have an opportunity, and vast responsibility, when it comes to international research about medical cannabis. Israel has a government-sponsored medical cannabis program and a convenient regulatory climate for research. We also have the health maintenance organizations, which possess rare databases of precious information about the effects of cannabis on thousands of patients who have undergone that treatment.”—Mimi Peleg Continue reading

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Cannabis

Dr. Sanjay Gupta: "Sometimes marijuana is the only thing that works"

Dr. Sanjay Gupta says we have been “systematically misled” on marijuana… Take the case of Charlotte Figi, who he met in Colorado. She started having seizures soon after birth. By age 3, she was having 300 a week, despite being on seven different medications. Medical marijuana has calmed her brain, limiting her seizures to 2 or 3 per month.

Continue reading

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Cannabis

Marijuana—God’s Creation—in Forever, and Eternity

I wonder what God is going to do with marijuana in eternity.

Out of all humanity alive today, I wonder what percentage DOESN’T take a pharmaceutical prescription? Remember, someone dies in the United States every 19 minutes from a prescription drug overdose, mostly accidental.

God created marijuana, and Christ warned about *pharmakeia* in the last days (Revelation 9:21, 18:23, 21:8, 22:15; Galatians 5:19-22) as “sorcery” by which “all the nations were deceived”.

Sounds like the pharmaceutical industry, doesn’t it?

Certainly “all nations” aren’t going to be deceived by God’s own creation: “nor height nor depth **nor any other creation** will be able to separate us from God’s love that is in Christ Jesus our Lord.”

“For **the creation** was subjected to futility, not by its own will but through him that subjected it, on the basis of hope that the creation itself also will be set free from enslavement to corruption and have the glorious freedom of the children of God. For we know that **all creation** keeps on groaning together and being in pain together until now.”

God created coca leaves—coco leaves are soaked in gasoline and sulfuric acid to produce the substance cocaine.

My Peruvian acupuncturist had me chew coco leaves to adjust to altitude for the hike to Machu Picchu.

Even Sanjay Gupta, MD finally does research instead of simply following the crowd.

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Cannabis, Neuroscience

Carolina Parents Push for Medical Marijuana

By Molly.Parker@StarNewsOnline.com
Published: Saturday, September 21, 2013 at 10:00 p.m.
Matt and Annetta Saggese work on speech and physical therapy with their daughter Netta at their Wilmington home. Netta has intractable epilepsy and undergoes various therapies throughout the week. Her parents want her to have access to medical marijuana.

Matt and Annetta Saggese work on speech and physical therapy with their daughter Netta at their Wilmington home. Netta has intractable epilepsy and undergoes various therapies throughout the week. Her parents want her to have access to medical marijuana.

North Carolina parents of children who suffer severe seizures are lining up for access to and pushing for legalization of medical marijuana where it’s not already allowed.

They want people to know they’re not radicals. And they’re not going rogue. They are searching for options.

They freely admit they are desperate parents staring down nightmares with their children, having watched them develop early skills only to lose them at the hands of numerous seizures, only to have tried cocktails of medications with debilitating side effects and watch them not work.

They want the option legal in this state to try medical marijuana. They want it so they aren’t forced to uproot and move to another state where it’s legal, where there’s been early success in treating seizure disorders. Continue reading

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"We in Israel have an opportunity, and vast responsibility, when it comes to international research about medical cannabis. Israel has a government-sponsored medical cannabis program and a convenient regulatory climate for research. We also have the health maintenance organizations, which possess rare databases of precious information about the effects of cannabis on thousands of patients who have undergone that treatment.
Cannabis, Neuroscience

The Quiet Giant: Israel’s Discreet and Successful Medicinal Cannabis Program

by Lindsay Stafford Mader, HerbalGram. 2013; American Botanical Council, Issue: 97 Page: 38-45

Despite its status as one of the world’s leading nations for medical research and innovation, the United States has a remarkably restrictive system in place to regulate medicinal cannabis research.

Even when the US Food and Drug Administration (FDA) approves medicinal cannabis studies, the researcher or institution must then obtain approval from the Public Health Service (PHS), as well as procure cannabis material from the National Institute on Drug Abuse (NIDA), which has a monopoly on the supply of cannabis that can be used for research throughout the entire country.1

Cannabis (Cannabis spp. Cannabaceae) is the only scheduled substance for which PHS approval is required, and those wishing to study the plant often have been rejected by the agency — effectively quelling this important area of science.

An increasing number of US states have taken matters into their own hands by legalizing medicinal cannabis for residents with certain health conditions.

But the federal government continues to raid and shut down state-based medicinal cannabis operations, even sending some of these business owners to prison.

Although the US situation is largely based on the discrepancy between state and federal law, Americans and citizens of other countries that ban medicinal cannabis could learn just how successfully, compassionately — and non-controversially — such a program can be handled by looking at the unique national medicinal cannabis program in Israel.

Continue reading

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Cannabis, Neuroscience

Drivers stoned on marijuana test their driving skills

If you watched this video and liked Addy, you can watch outtakes of her here: http://kiro.tv/WFNEMZ CNN may have just posted their best piece of investigative journalism in years. In the following video, three drivers of varying ages got incredibly high on marijuana and test-drove cars around a course. A driving-ed instructor accompanied them to avert any chance of an accident, and police watched from the sidelines to spot any visible ‘signs’ of inebriation in their movements.

The volunteers — a young daily smoker, adult weekend smoker and elder infrequent smoker — proceeded to test escalating levels of stupor against the new baseline ‘legal limits’ in Colorado and Washington state. They had to reach excesses of 5 times the legal limit before their ability to drive became impaired. In most cases, the danger they presented was driving too slowly or with frequent hesitations.

Continue reading

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Ancestry, Cannabis

Bubby

Randy at Hell's Point, Pokagon, Labor Day 2012

I am proud of my mother.

She challenged the authority when they told her that my uncle had six months to live.

In her heart, she knew better. In six weeks he was dead.

My mother didn’t fight the authority, there was no point. Either way, he’d be dead. Yet, my mother took her belief seriously. She rearranged her priorities, so that she could be with him not wanting to miss spending time with him while he still breathed.

My mother shared her belief with those of the family who would listen, and some believed what she, in faith, said. Because my mom is something of a natural nut, some chose to believe the word of the medical authority over what she so strongly believed.

My mother called us together, asking the family to gather, to spend time with him. The doctors had decreed his six months in July, my mom come and see him Memorial Day. I questioned my mother, asked her, is it Labor Day you mean? More than her words, I knew what she meant, what her belief would mean.

Schaadt's in Hell

Those of who believed, who took the health nut my momma seriously, took heed. The family all gathered, and the other side of the family hosted, the ones who take my mom seriously. Amid music and singing, children playing and sunflowers, my aunt and uncle (of that side of the family) offered Uncle Randy relief in the form of a weed. Though it’s not an appropriate natural remedy in my mother’s belief, it was thanks to God’s creation that he was able to join in the merriment, raising a guitar to his knee. Before that day, I never he knew that he could really play.

Uncle Randy

Later I confessed to my mother that she must know that the pleasure thanks to the leaves of a weed. I urged her to urge his caregiver to implore his doctor to prescribe him the prescription, mans form of God’s gift by the hand of their own authority. My aunt, the caregiver, and my mother agreed, though the need was plain to see, relief shouldn’t be obtained in the form of what they’d call “weed“, they apparently don’t approve whether relief is by a pill form prescription or by what he’d breath, or eat. I’d never make it home fast enough to see about sending him cookies.

That was the last day I’d really see him, that day watching the last of his life—more so than any other day I’d ever seen—as he laughed and he played and he drank and even sang. That night, still relieved, apparently was the last and only he’d really sleep. Later I here he spent hours dead to the world, but even a caregiver, I imagine if I am bold, will note the difference between succumbing to death and breathing easy in sleep.

All this is to say, that I’m proud of my mother and that though they’d say that he’d have six months in this life to remain. My mother, though others would think her insane, ignored the authority and in her campaign we thus would win the last few days we’d never get back again. Those who’d doubt totally missed out, but my mother made sure we had all the time with him that we could spend.

I think of my mother happy that she’d challenge authority. What they said she simply couldn’t believe. They say that ‘faith is the assured expectation of things not yet beheld’, and it takes faith to believe.

Had my mother held to her faith, and urged us to believe, I wouldn’t have seen my uncle and get to say goodbye, in not so many words, before he’d leave.

My dear parents, my sisters and my brother, I’m glad we all listened to our mother, listened to her, trusted, had faith and believed—even though we weren’t raised to question authority.

Momma didn’t try to fight the authority, and neither will I.

Momma at the Lake, Labor Day 2012

I believe that we’ll all obtain life, given the lives we live, when we die. The difference is simply the reward you’ll obtain, by what words we heed while in this life we remain. I think of Nikki, who momma’s words didn’t heed, she heard but didn’t listen, and by doubt missed out because it was the doctor’s she chose to believe. She said she’d see him later, and though in this life she was wrong, I imagine that one day the band will get back together, and we all will be there to sing along.

Grandpa, Me, and Uncle Randy

I hope that you’ll respect me, as I take my leave from believing what I was taught is the authority. I asked them questions they couldn’t answer, so I’ll believe what I read. The Word became flesh so that we could believe, and God left us a written record for us to read. He planted faith among us, a tiny little seed. Buried like our uncle and father, all it takes now to raise from up under is to read and believe! I will not try to uproot you from the soil you know, recalling God’s creation: seed, sun and water—we reap what we sow; a man planted, a man watered, but it was God that kept making it grow.

Then God said,

“I’ve given you every sort of seed-bearing plant on Earth And every kind of fruit-bearing tree, given them to you for food. To all animals and all birds, everything that moves and breathes, I give whatever grows out of the ground for food.”

And there it was.

God looked over everything he had made; it was so good, so very good!

It was evening, it was morning—Day Six. — Genesis 1

 

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Cannabis, Neuroscience

Marijuana and Coffee are Good for the Brain?

Marijuana and Coffee are Good for the Brain discusses what happens to our brains as we age. Low doses of marijuana seem to stimulate the brain in positive ways. Coffee acts as another stimulant that is proving helpful. Professor Wenk also talks about the best method to slow down the aging process.

Do you know what will really keep you living and thinking clearly for a long time? Dr. Wenk does. His research explores the intersection of food and drugs and will challenge your biases on what makes a long life. His talk will explore why what we eat, and how much we eat, is the single most important daily decision we make that impacts how we age and how long we live.

Mary Jane Meets Tia Maria

weed coffee Weed Coffee Recipe   Mary Jane Meets Tia Maria

Image source: themadpothead

As in Turkish coffee houses, or in bars of 16th century Amsterdam, this recipe has been a favorite for centuries.

Ingredients:

  • 300 milliliters (½ pint) hot fresh coffee
  • 1-2 grams finely ground hash
  • ½ teaspoon caster sugar
  • 1 tablespoon of Tia Maria

Directions:

Brew some fresh coffee and divide it into two cups. Add the sugar, liqueur and hashish to each. Top with whipped cream and dust in cocoa.

Recipe care of Good & Baked, “combining two of life’s sweetest pleasures”. 

 

Selected Publications of Gary Wenk, professor of Psychology and Neuroscience at The Ohio State University 

See also Your Brain on Food: How Chemicals Control Your Thoughts and Feelings.

  • Gold, P.E., Cahill, L., & Wenk, G.L. (2003) The lowdown on Ginkgo biloba. Scientific American, April, 86-91.PDF
  • Doody, R.S., Mintzer, J.E., Sano, M., Wenk, G.L. & Grossberg, G.T. (2003) Alzheimer’s disease: Emerging noncholinergic treatments. Geriatrics, (Suppl) 3-11.
  • Wenk, G.L. (2003) Neuropathologic changes in Alzheimer¹s Disease. Journal of Clinical Psychiatry, 64 (Suppl 9): 7-10. PDF
  • Rogawski, M. & Wenk, G.L. (2003) The neuropharmacological basis for Memantine in the treatment of Alzheimer’s disease. CNS Drug Reviews9: 275-308. PDF
  • Wenk, G.L., McGann-Gramling, K., Hauss-Wegrzyniak, B., Ronchetti, D., Maucci, R., Rosi, S., Gasparini, L. & Ongini, E. (2004) Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. Journal of Neurochemistry89: 484-493. PDF
  • Wrenn, C.C., Kinney, J.W., Marriott, L.K., Holmes, A., Harris, A.P., Saavedra, M.C., Starosta, G., Innerfield, C.E., Jacoby, A.S., Shine, J., Iismaa, T.P., Wenk, G.L. & Crawley, J.N. (2004) Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor. European Journal of Neuroscience,19:1384-1396.
  • Wenk, G.L. (2004) The role of BDNF and dopamine dysfunction in autism, In: M.L. Bauman & T.L. Kemper, (Eds.) The Neurobiology of Autism, 2nd Ed., The Johns Hopkins University Press, Baltimore, MD, pp. 362-370.
  • Gasparini, L., Ongini, E. & Wenk, G.L. (2004) Non-steroidal anti-inflammatory drugs (NSAIDS) in Alzheimer’s disease: old and new mechanisms of action. Journal of Neurochemistry91: 521-536. PDF
  • Mohmmad Abdul, H., Wenk, G.L., McGann-Gramling, K., Hauss-Wegrzyniak, B. & Butterfield, D.A. (2004) APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer’s disease. Neuroscience Letters368: 148-150. PDF
  • Rosi, S., Ramirez-Amaya, V., Vazdarjanova, A., Worley, P.F., Barnes, C.A. & Wenk, G.L. (2005) Neuroinflammation alters selective patterns of behaviorally induced Arc expression in the hippocampus.Journal of Neuroscience25: 723-731. PDF
  • Rosi, S., Pert, C.B., Ruff, M.R., McGann-Gramling, K. & Wenk, G.L. (2005) CCR5 chemokine receptor antagonist DAPTA reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer’s disease. Neuroscience, 134:671-676PDF
  • Rosi, S., Vazdarjanova, A., Ramirez-Amaya, V., Worley, P.F., Barnes, C.A. & Wenk, G.L. (2006) Memantine reduces the consequences of chronic neuroinflammation and restores the hippocampal pattern of behaviorally-induced Arc expression. Neuroscience142:1303-1315. PDF
  • Wenk, G.L. (2006) Neuropathologic changes in Alzheimer’s disease: Potential targets for treatment. Journal of Clinical Psychiatry, 67:3-7. PDF
  • Wenk, G.L., Parson, C. & Danysz, W. (2006) Potential role of NMDA receptors as executors of neurodegeneration resulting from diverse insults – focus on memantine. Behavioral Pharmacology 17: 411-424. PDF
  • Marchalant, Y., Rosi, S. & Wenk, G.L. (2007) Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of Alzheimer’s disease. Neuroscience, 144:1516-1522. PDF
  • Marchalant, Y., Cerbai, F., Brothers, H. & Wenk, G.L. (2008) Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats. Neurobiology of Aging, 29:1894-1901. PDF
  • Wenk, G.L. & Marchalant, Y. (2009) Neuropharmacology. In: G.G. Berntson & J.T. Cacioppo, (Eds.) Handbook of Neuroscience for the Behavioral Sciences, John Wiley & Sons.
  • Wenk, G.L. (2009) Neuroanatomy of learning and memory. In: D.S. Charney, E.J. Nestler, & B.S. Bunney, (Eds.) Neurobiology of Mental Illness, 3rd Ed., Oxford University Press, New York, NY.
  • Marchalant,Y.,Brothers,H.M.,Norman,G.J.,Karolina,K.,DeVries, C. & Wenk, G.L. (2009) The differential role of endocannabinoid and vanilloid receptors in the control of neuroinflammation and neurogenesis in aged rats.Neurobiology of Disease, 34: 300-307. PDF
  • Rosi, S., Ramirez-Amaya, V., Vazdarjanova, A., Esperanza, E., Larkin, P., Fike, J.R., Wenk, G.L. & Barnes, C.A. (2009) Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine. Brain, 132:2464-2468. PDF
  • Marchalant, Y., Brothers, H.M. & Wenk, G. Wenk, (2009) Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain. Molecular Psychiatry, 14:1068-1071. PDF
  • Brothers, H.M., Marchalant, Y., & Wenk, G. L. (2010) Caffeine attenuates lipopolysaccharide-induced neuroinflammation. Neuroscience Letters, 480:97-100. PDF
  • Norman, G.J., Morris, J.S., Karelina, K., Weil, Z.M., Zhang, N., Al-Abed, Y., Brothers, H.M., Wenk, G.L., Pavlov, V.A., Tracey, K.J., DeVries, A.C., (2011) Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic ?7 nicotinic receptors. Journal of Neuroscience, 31:3446-3452.PDF
  • Marchalant, Y., Baranger, K., Wenk, G.L., Khrestchatisky, M. & Rivera, S. (2012) Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention? Journal of Neuroinflammation PDF
  • Bardou, I. DiPatrizio, N., Brothers, H.M., Kaercher, R.M., Baranger, K., Mitchem, M.R., Hopp, S.C., Wenk, G.L. & Marchalant, Y. (2012) Pharmacological manipulation of cannabinoid neurotransmission reduces neuroinflammation associated with normal aging. Health. PDF
  • Cerbai, F., Lana, D., Nosi, D., Petkova-Kirova, P., Zecchi, S., Brothers, H., Wenk, G. L. & Giovannini, M.G. (2012) The neuron-astrocyte-microglia triad in normal brain aging and a model of neuroinflammation in the rat hippocampus. PlosOne PDF
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Cannabis, Neuroscience

The Munchies, Marijuana and Happiness — Psychology Today

Link: The Munchies, Marijuana and Happiness | Psychology Today

When we are depressed our brains undergo many different biochemical changes; no one is quite certain which of these actually cause the typical feelings of sadness or hopelessness.

One important depression-related change is a dramatic decline in the birth of immature neurons, known as neurogenesis, in a brain region called the hippocampus.

Drugs that treat depression, such as Prozac and Zoloft, all induce a recovery in the rate of neurogenesis in the hippocampus.

So what’s the connection with marijuana and the munchies?

The drug, rimonabant, that was so successful in reducing food cravings as it induced depression and thoughts of suicide, has been recently shown (by Beyer and colleagues at Pfizer) to significantly reduce neurogenesis.

Let’s flip this idea on its side and ask, “What would happen to neurogenesis if we exposed the brain to marijuana?”

My lab investigated this idea and discovered that a small dose of marijuana, about only one puff, taken every day can reverse the age-related decline in neurogenesis that might underlie depression.

Whether this approach might also work in young people remains to be determined.

What these studies teach us is that our brain’s own marijuana neurotransmitter system is necessary for us to feel hungry, to experience happiness and to maintain the brain normal processes, such as neurogenesis, that prevent age-associated depression and cognitive decline.

We’ve learned from our experience with rimonabant that it is dangerous to constantly antagonize this neurotransmitter system.

What we do not know is whether it is dangerous to constantly stimulate it.

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Cannabis, Neuroscience

Diagnosis!

From: Angela M. Baxley
Date: May 18, 2011 1:19:46 AM EDT
To: BAY
Subject: Diagnosis!

I have a diagnosis: hyperthymic temperament with [drug induced episodes of] hypomania.

Talked to a doctor today (see below). We talked for a little more than an hour, over the phone. He ruled out epilepsy (if a concern, past as childhood) and manic/bipolar, depression.

He said there isn’t much a treatment. Continue Serofin, likely that can reduce “need” for effects of MJ. Should know in about 1 month.

Half-life for Clonazepam is extremely long and he was not at all surprised by any of my experiences.

Apparently I’ll just live with hypothymic [sic] temperament the same way Micheal just lives with dysphoria. I’m the euphoria to his dysphoria. No wonder I was so attracted to him. I always felt he gave me that other half of life perspective.

@ang @baxley

 


 

Begin forwarded message:

From: “Vishaal Mehra”
Date: May 16, 2011 3:56:03 PM PDT
To: “‘Angela M. Baxley'”
Subject: RE: Request

Hi Angela

Clonazepam (and other benzodiazepine medication) can have an atypical response in some individuals, such as disinhibition, mood changes, and activation—rather than the expected calming/sedation often seen with these types of meds.

Would you like to talk over the phone to discuss your symptoms further?

I have some availability this week

Let me know

Vishaal

Vishaal Mehra MD, CPI
CEO and Medical Director
Artemis Institute for Clinical Research
8787 Complex Dr, Ste 100
San Diego, CA 92123
Office: (858) ARTEMIS (278-3647)

 


 

From: Angela M. Baxley
Sent: Monday, May 16, 2011 3:35 PM
To: Vishaal Mehra
Subject: Re: Request

Hi Vishaal,

Thank you for helping. Matt is a great guy, and I appreciate all his help as well.

I have had unusual symptoms from what I can recall around 15 or so up to today. I would like to see who might be able to professionally guide my search for understanding.

I recently had a panic attack with which I took 2 Clonazepam. That sent me into a rage. That sent me to Wikipedia, where I learned that much of what’s been “wrong” may all be due to the medication.

Please let me know what you need from me.

And once again,
Thank you.

Angela

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